Dengue fever, an acute arthropod borne febrile disease, infects 50-100 million people annually. Indonesia is ranked second out of thirty endemic Dengue Hemorrhagic Fever (DHF) countries from 2004-2010. According to Indonesia’s ministry of health, there are 60,296 cases of dengue fever up until April 2024 resulting in 455 deaths.The high infectivity rate and unavailability of drugs that hav…
Apple (Malus domestica) is the second most popular fruit for processing globally due to its high nutritional value. However, with the increasing health consciousness, consumers are looking for foods and beverages with health-promoting benefits and nutritional value. Thus, the demand for functional foods and beverages with prebiotic properties.
Lipid-based dairy free RUCF is a ready to use complementary food made with local ingredients. The important quality of the RUCF is the nutrient composition and physicochemical properties, especially the oil separation and PV. With the problems encountered with oil separation in previous study about development of lipid-based dairy free RUCF, this study will reformulate the RUCF with adjuste…
Kombucha is a fermented tea product, which recently innovated by using fruit juices, herbs, and natural extract to create novel taste. This study, explored black sapote (Diospyros nigra) potential as tea replacement to create novel taste and its antioxidant content, which beneficial to reduce non communicable disease. SCOBY act as starter culture, containing AAB and yeast, contributed to ko…
As a fruit, apple provides a considerable amount of bioactive compounds, including antioxidant and anti-inflammatory compounds. It is known as rapidly perishable food and is usually processed into apple juice in order to prolong its shelf-life. Conventional apple juice processing utilizes the thermal treatment that may cause the degradation of bioactive compounds. Alternatively, a hurdle of…
Developing Texturized Vegetable Protein (TVP) from alternative sources is crucial in addressing the concerns associated with soy-based TVP. This study explores the potential of rice bran and mung bean as sustainable and nutritious alternatives to soy in TVP production. The samples were formulated to produce TVP with 55% protein based on the materials: soy (S-TVP) as control, soy and rice bra…
The prevalence of celiac disease has increased significantly over the past decades due to people’s growing knowledge and awareness of the disease, as well as recent advances in its diagnostic tests. This causes the rise of gluten-free foods, including gluten-free bakery goods. Out of all gluten-free flours, rice flour has been recognised as the most suitable flour for gluten-free bakery go…
Centella asiatica has been used for medicine, pharmaceuticals, and food supplementation, owing to its high phenolic and flavonoid content, as well as its significant antioxidant activity in the leaves. The need to transform its extract into powder form using microencapsulation is currently emerging, enabling convenience and versatility for various food industrial applications. Spray drying i…
Malaria, caused by Plasmodium parasites and transmitted by Anopheles mosquitoes, is a significant public health issue, particularly in South and Southeast Asia where Plasmodium vivax is prevalent. Understanding the genetic factors influencing mosquito susceptibility to P. vivax is crucial for developing targeted malaria control and eradication strategies. Building on previous findings that …
This study investigates the anti-inflammatory properties of Andaliman (Zanthoxylum acanthopodium DC.) fruit extract on inflamed human keratinocytes (HaCaT cells). The phytochemical profile of Andaliman reveals a high content of terpenoids from the Salkowski test, which inhibits the NF-κB signaling pathway, thereby suppressing pro-inflammatory cytokine production. The study demonstrates a s…
Candida albicans is a yeast that resides on the human skin, however it can become an opportunistic pathogen when the immune system is compromised or there are imbalances in the microenvironment. This microorganism can cause candidiasis which is able to cause high mortality rates in especially immunocompromised patients. Treating this infection is highly difficult due to similarities in stru…
Humans have been co-existing with a whole population of microbes, where trillions of different microbes are living inside the human GI tracts as a commensal gut microbiota. This condition provides a mutual relationship where the gut microbiota serves as a natural protection for the intestinal tract homeostasis. Nevertheless, the human intestinal tract is constantly exposed to environmental …
Cancer remains a global health challenge in need of precise, cost-effective, and scalable research tools for comprehensive investigations. Spheroid-based methodologies emerge as reliable, easily adaptable, and highly scalable techniques, offering an improved representation of in-vivo conditions compared to conventional 2D cell cultures. This study utilizes the Huh-7 cell line to generate hep…
This research aims to develop an alcohol free craft beer utilizing Momordica charantia, otherwise known as bitter melon, as a hops substitute. This study substitutes hops with 0%, 25%, 50%, 75%, and 100% of bitter melon. The alcohol free beer was prepared by malting, mashing, brewing, fermentation, and incubation, followed by giving heat treatment to the beer separating them into non-heat t…
Plant-based or non-dairy milk substitutes are becoming favored in the growing field of functional beverages driven by factors such as health benefits, allergies, lactose intolerance, and the rise in vegan diets. However, there are challenges to producing oat milk, such as achieving the desirable texture and taste. This study is aimed to have 4 treatments utilizing 2 different kinds of amylas…
Bread is widely favoured food due to simple composition and convenient suitability for daily consumption. One of the main ingredients used to determine the bread quality is yeast. As the Indonesian bread industry has grown, bread is being processed by replacing instant yeast with natural yeast because of increasing consumer interest natural products. Natural yeast is obtained from fermented…
Glioblastoma (GBM) is known as a highly aggressive and malignant form of brain cancer. Despite advances in understanding the genetic and molecular basis of glioblastoma, it has a poor prognosis with a median survival rate of 9 months. The complex interplay between malignant cells and the surrounding tumor microenvironment (TME) plays a pivotal role in tumor progression and treatment respons…
This study focuses on the characterization of bacterial communities in Takakura compost specifically applied to Saga plants. Takakura compost, known for its simplicity, cost-effectiveness, and efficacy in producing high-quality compost, utilizes the natural processes of microorganisms to break down organic materials. The research involves the analysis of bacterial communities during the comp…
Bacterial cellulose (BC) is a promising packing material as it is biodegradable, non-toxic, has good mechanical properties, and can form bonds with foreign particles. Meanwhile, P. acidilactici postbiotics (metabolites) have the potential to be a natural food preservative as they contain antimicrobial compounds that are heat- and pH-stable. This research aims to develop a novel antimicrobia…
Hydroponic cultivation has emerged as a cost-effective alternative to traditional soil-based agriculture and may be less susceptible to pests and diseases. They can be set up in controlled environments, making them suitable for year-round production in urban areas with limited land availability. EM4 is a type of fertilizer that can increase agricultural systems' decomposition, composting, a…
Wound dressings play a crucial role in promoting efficient wound closure and healing by providing an environment conducive to tissue repair. Traditional wound dressings, such as cellulose-based gauze, often exhibit challenges in adhesion and exudate absorption, necessitating frequent replacements that may cause additional trauma. Biocellulose (BC), derived from bacteria, presents a natural c…
Bacterial cellulose (BC) is a biopolymer currently being coveted for its versatility, sustainable sourcing and biodegradability. The Indonesia International Institute for Life Sciences (i3L) lab has been conducting research on BC fermentation and surrounding BC produced by the kombucha isolate Komagataeibacter intermedius, with past findings showing a great prospect of the bacteria being abl…
The therapeutic benefits from the utilization of the roots and leaves saga plant have been known to Asian cultures for centuries. Numerous studies have attributed the therapeutics properties to triterpenoids, a class of secondary metabolites found in plants that are produced by the plant defense system under stressful environmental conditions. Recent study in legume model plant, lotus japon…
Black sapote is an underutilized fruit with various bioactive compounds and medicinal properties. To increase its utilization and value, the black sapote was turned into kombucha and spray-dried to increase the shelf life and stability of its active components. Encapsulating agents are used to protect the bioactive compounds during spray drying. This study investigated the effect of ferment…
The demand for fresh-cut fruits and vegetables (FFVs) has expanded due to consumer preferences for nutrition, safety, convenience, and ready-to-eat. However, FFVs are highly susceptible to surface browning and microbial spoilage. Active packaging (AP) offers a promising method to enhance shelf life and quality of FFVs. In this study, cellulose acetate-based active packaging films infused wi…
Dry eye disease (DED) is a common ocular disorder with multiple underlying causes. Carboxymethylcellulose sodium (CMC-Na) is frequently used in artificial tear formulations to alleviate DED symptoms. Different CMC-Na types from various brands can exhibit varying degrees of substitution (DS) and viscosity, leading to variations in filtration process performance and stability in formulations.…
Keratoconus presents a significant challenge in ophthalmology, urging effective treatment strategies to mitigate its impact on patients’ lives. This study investigates the safety and efficacy of combined therapy, utilizing rose bengal (RB) and riboflavin (RBF) for keratoconus management. Through ex vivo and in vitro experiments, significant increases in corneal stiffness and cell viability…
The skin is a vital outer layer that serves as protection. Once the protective layer is disrupted, for example the formation of wounds due to outer layer damage, it may increase the likelihood of contraction skin infection, which is a global burden. When open wounds are in contact with microorganisms, it allows attachment and proliferation, resulting in the development of biofilms. Antibiot…