Enhancing the utilization of local agricultural and marine products is one of the approach in empowering the local economy. Sago, anchovies, and macroalgae are the examples of underutilized resources in Indonesia, despite their significant potential. In this research, sago flour is used to develop gluten free noodles as noodles are one of the most often consumed food by Indonesians. However…
The crosstalk between natural killer (NK) cells and adipose tissue has gained significant interest due to its critical role in shaping the adipose tissue microenvironment and influencing metabolic homeostasis. It is now widely acknowledged that the activation of NK cells and macrophages in visceral adipose tissue (VAT) during obesity strongly contributes to insulin resistance. However, curre…
Glioblastoma (GBM) is the most severe type of brain tumor with poor prognosis and low survival rate, characterized by molecular heterogeneity and immunosuppressive microenvironment which pose a significant challenge in improving treatment strategies. It is found that the abundance of tumor- associated macrophages (TAMs) in the GBM microenvironment contributes significantly to tumor progre…
Oral Squamous Cell Carcinoma (OSCC) is one of the leading malignant tumors worldwide. The oncogenic long non-coding RNA (IncRNA), LncX, was reported to play a critical role in OSCC progression. To further identify and characterize the key pathways and genes downstream of LncX, we will integrate online datasets and bioinformatic analysis to investigate the expression pattern of LncX in OSCC and …
Pancreatic ductal adenocarcinoma (PDAC) is characterized by poor prognosis, being commonly diagnosed in the unresectable advanced or metastatic stage which poses an extremely poor prognosis for patients. Hypoxia predominates most pancreatic cancer tumour microenvironments (TME), with HIF-1 signalling being overexpressed in 88% of all pancreatic cancers. Long noncoding RNAs (lncRNAs) have emerge…
Wheat is one of the food sources in Indonesia that has one the highest consumption rates. With the rise in the consumption rate of wheat in Indonesia over the past year, the Indonesia’s government has to increase its import activity on wheat to maintain its supply. This can also cause most of Indonesian society to have high dependency towards the consumption of wheat. However, currently t…
The overarching goal of this project is to comprehend the intricate dynamics of RNA viruses, specifically influenza A viruses, enteroviruses, and coronaviruses, which pose significant health threats. The focus lies in exploring hostvirus interactions, particularly the roles of host components in various stages of viral RNA replication, aiming to identify potential targets for antiviral interv…
Dysregulation of the ubiquitin-proteasome system (UPS) leads to the accumulation of aggregationprone proteins which has been linked to neurodegeneration and cancer. The 26S proteasome is acentral component of the UPS. It assembles by the successive recruitment of the 33 different proteasome subunits which is assisted by proteasome assembly chaperones: five for the CP and five for the RP. RPAC…
Plant-based milk alternatives have been given increasing importance by consumers in recent years due to their concerns towards the health, environment, and dietary lifestyle of cow’s milk. No prior study has explored the factors influencing the consumer behavior towards plant-based milk alternatives (PBMAs) within a unified framework. Therefore, this study attempts to predict the factor affec…
The demand of a food preservative has been increasing due to foodborne diseases due to foodborne pathogens. Moreover, there is also an issue on the health risks caused chemical food preservatives, further increasing demand on a safer food preservative. Recently, Pediococcus acidilactici has been gaining interest as a potential natural food preservative due to its ability to produce pediocin,…
Prostate cancer (PC) is a heterogeneous disease that has a slow progression compared to other types of cancers, where the severity of prostate cancer commonly increases along the age of each individual. PC is still considered as a global disease and its development is affected by racial differences. African-American (AA) men are proven to be more susceptible to PC compared to European-Ame…
Rhizocephala members have the ability to manipulate its decapod hosts’ behavior, anatomy, and physiology. The immune system of Rhizocephala and the effect of Rhizocephala infections on immunity of parasitized crabs have not been discussed. This study describes the expressions of several immune-related genes in Polyascus planus (parasitic barnacle)-parasitized Metopograpsus thukuhar and in…
The demand of a food preservative has been increasing due to foodborne diseases due to foodborne pathogens. Moreover, there is also an issue on the health risks caused chemical food preservatives, further increasing demand on a safer food preservative. Recently, Pediococcus acidilactici has been gaining interest as a potential natural food preservative due to its ability to produce pediocin,…
Color is one of the major attributes that affects the consumer perception of tea quality. Color change of the product might be clearly seen in the RGB due to its transparent appearance. Tea-based products in Returnable Glass Bottle (RGB) is one of the most popular products launched by PT. Sinar Sosro, including S-Tee. By launching RGB products, PT. Sinar Sosro needs to maintain product quali…
PT. Etana Biotechnologies Indonesia (or “Etana”) plans to produce mRNA vaccines on a large-scale basis. To ensure product and batch qualities, it is imperative to implement the cleaning validation program. Cleaning validation is a procedure which ensures that there are no residues of Active Pharmaceutical Ingredients (APIs) left after the cleaning process. It is generally performed as pa…
Zika virus is a mosquito-borne Flavivirus and is additionally transmitted by sexual contact, across the placenta and by blood transfusion. The spread of the Zika virus is also of concern in Indonesia, considering that Indonesia is a tropical country and an endemic area for dengue fever every year. There is currently no vaccine available to protect against or drug to treat Zika virus infect…
SARS-CoV-2 began its outbreak in the late December of 2019 and was later declared as a global pandemic. It has led to the research of therapeutics and vaccines development for SARS-CoV-2 as a method of treatment. The target genes for the immunotherapeutic construct are usually the spike protein due to its crucial binding to the human ACE2 receptor via the RBD. Upon its entrance to the host …
PT ABC Kogen Dairy is a dairy company that has proven consistency in product innovation throughout the years. The marketing department, where the author had her internship, also contributes to product development projects focusing on the marketing attributes. Two yogurt projects will be discussed in this report, the first one is EPD which was conducted due to the inadequate performance of t…
Prostate cancer is commonly found among men above 65 years old, making it one of the most commonly found malignancies found worldwide. Prostate cancer lacks early signs or symptoms, making it hard to diagnose in the early stages. The late-stage diagnosis tendencies accompanied by the inherent resistance mutation capability of cancer make it a hard disease to cure. Recently advancements in the m…
Overripe or over-fermented tempeh is fermented 2 – 5 days longer than normal tempeh and commonly used as flavour enhancement. Studies on microbial changes were limited to 24 and 72 hours, while limited studies were available for internal microbial growth factors that affecting overfermentation process. Therefore, this study aims to evaluate the changes of microbial and internal microbial …
Sobotta - Atlas of Human Anatomy with online access: the exam atlas for understanding, learning, and training anatomy The English-language Sobotta Atlas with Latin nomenclature is specifically adapted to the needs of preclinical medical students. Right from the start, the book and the Internet content concentrate on exam-relevant knowledge. The new study concept simplifies learning-understandin…
RNA technologies are the driving forces of modern medicine and biotechnology. They combine the fields of biochemistry, chemistry, molecular biology, cell biology, physics, nanotechnology and bioinformatics. The combination of these topics is set to revolutionize the medicine of tomorrow. After more than 15 years of extensive research in the field of RNA technologies, the first therapeutics are …
The existence of genes for RNA molecules not coding for proteins (ncRNAs) has been recognized since the 1950's, but until recently, aside from the critically important ribosomal and transfer RNA genes, most focus has been on protein coding genes. However, a long series of striking discoveries, from RNA's ability to carry out catalytic function, to discovery of riboswitches, microRNAs and other…
RNA Interference (RNAi) technology has rapidly become one of the key methods used in functional genomics. RNAi is used to block the expression of genes and create phenotypes that can potentially yield clues about the function of these genes. In the postgenomic era, the elucidation of the physiological function of genes has become the rate-limiting step in the quest to develop 'gene-based drugs'…
What makes being a global business leader today such a complex task? It’s more than mastering your knowledge of various geographies and cultures, though that is essential. But to succeed, you must also master the complex mind-set and competencies needed to lead in today’s fully globalized world. Not an easy assignment.
Students, residents, and instructors swear by Andreoli and Carpenter's Cecil Essentials of Medicine because it presents just the right amount of information, just the right way. Edited by the late Thomas E. Andreoli, MD as well as Ivor Benjamin, MD, Robert C. Griggs, MD, and Edward J. Wing, MD, it focuses on core principles and how they apply to patient care, covering everything you need to kno…