Inflammation is a crucial part of the immune response, involving neutrophils, the predominant white blood cells, in combating pathogens. Their recruitment is regulated during inflammation, which can lead to conditions like autoimmune diseases and cancer. This study aims to explore meso- Dihydroguaiaretic acid (MDGA) derivatives, particularly MZ47, as potential therapeutic options for neut…
Phylogenetic distance estimation between taxa in a tree is critical for tree reconstruction. There exist several classical methods that are already established in the field of phylogenetics. However, these classical methods of distance estimation are not straightforward and their computation can be tedious. As neural networks show great success in pattern recognition tasks, it is reasonable tha…
Quality Control (QC) is important to ensure the identity, strength, purity, pharmacological safety, efficacy, and effectiveness of biopharmaceutical products. Biopharmaceuticals are complex drugs that are created from living cells or organisms, which frequently employ advanced biotechnological techniques. In the biopharmaceutical industry, tests are performed on the finished product to ensure t…
Shampoo is a type of hair care product that is used to clean the scalp and remove the dirt. Not only for humans, shampoo is also used for animals, especially dogs. However, different from human shampoo, dog shampoo tends to be milder due to the different pH and sensitivity of dog’s skin compared to human skin. It is important to formulate a shampoo that has good properties for dog characteris…
Phytoplasmas, which are bacteria that lack cell walls, are known to infect a variety of host plants and spread quickly within them including fruit plants and other types of flora causing significant agricultural losses. Phytoplasmas infect a wide variety of plants, causing irregular plant growth such as phyllody. Phyllody is a developmental transformation in plants that transforms flowers into …
PT. Phapros Tbk is a pharmaceutical company under the PT. Kimia Farma, which has a vision and several missions based on the fundamental pillars of trust, and holds firmly to the core value of AKHLAK. This company produces OTC medications, generic drugs, prescription drugs, and medical devices. Thus, in producing various pharmaceutical products, specifically the Quality Assurance (QA) department…
Photorhabdus insect-related toxins A and B (Pir A and Pir B) are two different types of insecticidal toxins that were firstly found in Photorhabdus luminescens. Its homolog, from Vibrio parahaemolyticus, is found to cause acute hepatopancreatic necrosis disease (AHPND) in the shrimp, since it contains plasmid pVA1. When binded together, Pir A and B can exert its effect, because they form a stru…
PT Phapros TBK is a pharmaceutical company founded in 1954, which is now owned and operated under PT Kimia Farma TBK. Research and development falls under the production department, which is one of the 3 main departments in PT Phapros. The Research and development team centers on drug development and analysis, among which Analytical development plays an integral part in the process. During this…
Dengue virus (DENV) poses a global health threat due to the high prevalence, with varying degrees of severity which can escalate to mortality. The disease burden is increased by the genetic diversity, resulting in serotypes and genotypes with different replication rate and clinical severity. This molecular diversity, especially prevalent in endemic regions like Indonesia, underlies the importan…
Neutrophils are the main cells that play a significant role in the innate immune system. Upon a pathogenic invasion, these cells are recruited to the site of infection and perform many different functions. Targeting the neutrophils for therapeutic interventions has been a great challenge due to the complexity of their signaling pathway and mechanisms. Therefore, the search for drug candidates t…
The medial habenula (MHb) is the less explored subregion of the emerging brain structure, Habenula (Hb) with roles in fear memory expression, anxiety, and addiction. At the neuron terminals where MHb neurons project to, the interpeduncular nucleus (IPN), vesicular neurotransmitter release is triggered by the influx of calcium ions via Ca v2.3 calcium channels, and robustly potentiated by GABAB …
Neutrophils are polymorphonuclear and phagocytic leukocytes that act as the first line of innate immune defense to protect and rapidly kill the invading pathogens from the human body. In general, neutrophils are essential immune cells that play a significant role in the early response to infections through their ability to migrate into affected tissues upon pathogens invasion. The activation of…
In recent years, the food industry develops functional food which produces health benefits to the customer and the beverage industry is a suitable sector to explore. Therefore, this project aims to develop a collagen drink using the Thong Pha Phum GI (Geographical Index) rambutan as a locally grown fruit in Thailand. The main objective is to observe the effects of different concentrations of ra…
The consumption of low or zero−calorie carbonated soft drinks (CSD) which utilize artificial sweeteners are growing in popularity as it can provide sweetness without adding calories. A blend of acesulfame−K and sucralose is known to exhibit good taste results in comparison to sugar−containing products. In this study, different concentrations of sweetening agents (100% sucrose, 60% sucrose…
The prevailing ubiquity of carbonated beverages in the consumer market is coupled with concerns regarding their high sugar content, which is implicated in health risks such as obesity, cardiovascular diseases, type II diabetes mellitus, and certain cancers. Acknowledging these health implications, PT Sinar Sosro is actively reformulating its products to reduce sugar content. This project focuse…
The internship at PT. Symrise, a global manufacturer of flavors and fragrances, offered valuable practical experience in the food industry, specifically in flavor application for the sweets and beverages department. Tasks included compounding prototypes, analyzing physicochemical properties, and contributing to sensory evaluations. The focus on developing flavors for diverse products, such as r…
Wolffia spp. had garnered attention as a potential "superfood" due to its reported nutritional value, offering a promising solution to the escalating global obesity crisis. Nonetheless, Wolffia spp. exhibits a moisture content of approximately 95% post-harvest, necessitating a drying procedure to reduce the microbial growth and facilitate storage, packaging, and transportation. This study focus…
The widespread consumption of jamu, a traditional herbal medicine, contributes to the accumulation of rhizome pomace (RP), a by-product generated during the water extraction of local rhizomes, such as black turmeric (Curcuma aeruginosa), white turmeric (Curcuma zedoaria), and aromatic ginger (Kaempferia galanga L.) used in jamu production. This study addresses the environmental challenge posed …
Celiac disease is a gluten-related disorder that is triggered when a person consumes gluten. This will cause the immune system to attack the tissue. This problem has caused society to demand more gluten-free foods, including cakes. However, gluten-free cakes have several challenges in that their texture is denser than wheat flour cakes. In this study, gluten-free cakes will be fortified with da…
Enzymatic hydrolysis can overcome the problem about the quality of the instant porridge. The process was divided into 3 steps, gelatinization, liquefaction, and saccharification. The glycosidic chain will be broken down by the amylase and turn the starch into a maltose and glucose that gives natural sweetness and better mouthfeel. Hydrolysis really depends on the temperature as the enzyme might…
Tea consumption in Indonesia is on the rise including Ready to Drink (RTD) tea. TehBotol Sosro is the one of the popular ready-to-drink (RTD) tea brand in Indonesia. Tehbotol Sosro is famously known for not having preservatives in its beverages. It only consists of water, tea, and sweetened with sugar and contains no artificial ingredients. The physicochemical properties, such as pH, brix level…
Increasing demand as well as interest for plant−based ingredients such as konjac was occurring. Additionally, in order to stabilize the prices, extend shelf life, and enhance added value of peaches, various processing methods and products must be developed. White peach has a good insight from the market due to its premium imported fruits that can't be cultivated in Indonesia. However, in this…
Staphylococcus aureus (SA) is an opportunistic human pathogen that can cause infections in humans, including atopic dermatitis, also known as eczema. Eczema is a skin condition where patients experience flare-ups characterized by redness, itchiness, dried skin, and may vary among individuals. Interestingly, there is a common pattern where all eczema patients' skin is colonized by SA, and treatm…
Noodles are a staple food in Asia. However, since it is made using wheat flour which is high in carbohydrate, protein enrichment by adding other ingredients like cricket powder and nutritional yeast can be done. This study aimed to increase the protein content in noodles by incorporating cricket powder and nutritional yeast with different substitution levels (10, 15, and 20%) towards the …
This study aimed to develop a lipid-based paste form of Ready-to-Use Complementary Food (RUCF) using locally available ingredients, while investigating the physicochemical changes during 21 days of storage. Three formulations were proposed and assessed using B one touch viscometer for viscosity, CS410 handheld colorimeter for color, pawkit water activity analyzer for water activity, and e…
Skin inflammatory disease such as psoriasis and atopic dermatitis still remains a major problem because of their chronic nature. Treatments for atopic dermatitis and psoriasis has been solely focused on symptom management. Recently, it has been reported that phytochemical compounds from Calophyllum inophyllum seed possesses anti-inflammatory activities. However, little is known about its anti-i…
Cacao (Theobrama cacao L.) is rich in antioxidants of polyphenols and flavonoids. Because of its antioxidant, cacao has many health benefical effects including antidiabetic. During chocolate production, fermentation becomes the most important part for cacao beans. This is because cacao will not produce great flavors without the fermentation. there are many cacao not in good quality because the …
Phytophthora infestans is a devastating disease that caused the unfortunate 1845 – 1852 Irish Famine, leading to 25% decline of the population of Irish people and still impacts the whole crop ecosystem in temperate potato growing regions. Therefore, scientists have been researching on preventions that are capable of preventing outbreaks and the spread of this pathogen. This project would like…
Milk-based drink is defined as a drink made using fresh milk, reconstituted milk, or recombined milk, which can be added with other food ingredients and sterilized or pasteurized. At PT. Garudafood, 40-50% of process water were incorporated into chocolate milk-based drink products, thus the quality of process water must be tightly regulated. This research was conducted to identify the impact of…
Soy sauce is a liquid condiment that is made from fermented soybeans with mold, wheat flour, brine water, bacteria, and yeast. Soy sauce fermentation includes two stages of fermentation which begins with koji fermentation and ends with moromi fermentation. Koji fermentation is a solid- state fermentation through the use of mold and it may last for 48 to 72 hours. Meanwhile, moromi fermentation …
Staphylococcus aureus is a bacteria that has gained significant attention due to the emergence of antibiotic resistance. Some of the factors that contributed to the development of antibiotic resistance are associated with the formation of biofilm. Abelmoschus manihot and Tinospora crispa are recognised to have antimicrobial activity and its expected to have biofilm inhibitory effect. In this…
People all around the world are shifting towards eating more plant-based food, the vegan consumers and communities are rapidly increasing. However, there is a challenge in the development of plant-based meat analogue to mimic the characteristics of animal based products, especially for the juiciness and textural properties. Hydrocolloids can be used to improve the quality attributes of plant-ba…
Japanese curry is a popular dish which contains a high amount of spices, which provides the dish with quite a considerable amount of antioxidant activity. Even if curry may contain a high amount of spices, curry itself also contains a moderate amount of fat and oil which is involved in its production. Due to the moderate amount of fat and oil in curry, the product will be susceptible to auto-ox…
Avocado seed is more useful than just being a byproduct of avocado processing since it contains a lot of phenolic compounds. However, the phenolic compounds are rather prone to be damaged by environmental stress and by applying encapsulation techniques, they can be protected from the environmental stress. Thus, this study focuses on researching the effect of the presence of core and the core be…
Avocado seed (AS), a by-product of avocado, contains a high level of polyphenols which contributes to total antioxidant capacities (TAC) of avocado. However, polyphenols need to be encapsulated due to their sensitivity towards environmental stress. This study only observed the effect of the presence of core, the emulsification, coacervation, and freeze-drying steps of complex coacervation, and …
Plant-based nugget (PBN) is a succulent and firm alternative to the chicken nugget with a meat-like texture. PBN often has low sensory acceptability compared to chicken nugget and the direct fat incorporation was reported to cause fat leakage during cooking and the effect was suboptimal. Therefore, the effects of structured fats (solid and liquid mixture) incorporation in the form of emulsion t…
This study observed the physicochemical and microbiological stability of plant based meatballs made from local ingredients which are vacuum packed and frozen. During frozen storage, deterioration happened gradually caused by microbial growth and physicochemical changes. Thus, the microbial content including bacteria (TPC), yeast and mold (TYMC), and physicochemical aspects including water a…
Overripe tempeh is tempeh that had been fermented for 2 – 5 longer than fresh tempe wherein mold fermentation ceases and taken over by bacterial fermentation. It is commonly used in traditional Javanese cuisine as a basic flavoring agent. Most of the studies of tempeh range from microbiology, chemical and nutritional changes, functionality and its sensorial aspect but information on overripen…
The growing awareness ofthe hazard of Bisphenol A has sparked a massive switch to its analog, Bisphenol S (BPS), which is deemed to be safer. However, the safety of this chemical is questionable as BPS shares considerable structural similarities with BPA and little scientific evidence backing up its safety. This thesis project was conducted to investigate the developmental effects, particul…
Breast cancer is the most common cancer in woman and the second leading cause of cancer deaths in the world among women. Research have shown the efiicacy of phytochecmicals as asupplementary treatment in breast cancer through the regulation of gene and microRNA (miRNA) expression. This study aims to identify differentially expressed miRNA-gene pairs in breast cancer across different stages in o…