This study investigates the anti-inflammatory properties of Andaliman (Zanthoxylum acanthopodium DC.) fruit extract on inflamed human keratinocytes (HaCaT cells). The phytochemical profile of Andaliman reveals a high content of terpenoids from the Salkowski test, which inhibits the NF-κB signaling pathway, thereby suppressing pro-inflammatory cytokine production. The study demonstrates a s…
Inflammation, although acts as the body’s defense mechanism, may progress into a chronic one when unregulated properly, causing chronic inflammatory diseases such as Crohn’s disease and obesity. Tape singkong or fermented cassava is a widely produced traditional fermented food in Indonesia, with numerous bioactive compounds that makes it a great potential to exert anti-inflammatory prop…
Enterohemorrhagic Escherichia coli (EHEC) strains infect millions annually with their ability to colonize the gut and form biofilms contributing to antibiotic resistance. Moreover, CXCL8 (IL-8), TNF-ɑ, and ICAM-1 are genes involved in the inflammatory host response against EHEC infection. Thymus vulgaris, generally known as common thyme, is a traditional medicinal plant with antibacterial …
Inflammation is a crucial part of the immune response, involving neutrophils, the predominant white blood cells, in combating pathogens. Their recruitment is regulated during inflammation, which can lead to conditions like autoimmune diseases and cancer. This study aims to explore meso- Dihydroguaiaretic acid (MDGA) derivatives, particularly MZ47, as potential therapeutic options for neut…
Skin inflammatory disease such as psoriasis and atopic dermatitis still remains a major problem because of their chronic nature. Treatments for atopic dermatitis and psoriasis has been solely focused on symptom management. Recently, it has been reported that phytochemical compounds from Calophyllum inophyllum seed possesses anti-inflammatory activities. However, little is known about its anti-i…
Inflammation is a biological response that can be initiated by the immune system. This response is vital as it aids in the healing of injuries and infections caused by foreign agents. Nevertheless, while acute inflammation serves a beneficial purpose, prolonged or chronic inflammation can detrimentally impact cellular, tissue, and organ health, potentially leading to internal scarring. Candlenu…
Inflammation plays an important role in the body as a defense mechanism against pathogens, toxins, and dead cells. However, when the infection continues and inflammation becomes unregulated, acute inflammation eventually progresses into a chronic one, which holds responsibility for numerous chronic non-communicable diseases such as cancer, hypertension, diabetes, etc. various foods have bee…
Atopic dermatitis (AD) is a common chronic inflammatory skin disease affecting almost 2.4% of the population worldwide. Due to the complex interactions of genetic, environmental, and immunological variables, AD is still incurable as the knowledge of this complex disease is still limited. Moreover, current available treatments can only treat its symptoms and stop them from getting worse. The…
Atopic dermatitis is a multifactorial chronic skin inflammatory disease characterized by acute flare-ups and exacerbations, chronic eczematous skin lesions on dry skin, as well as intensive pruritus. It affects 10-30% of children and 2-10% of adult worldwide with an early onset. Currently, there has been no treatment that can address this disease completely. This research is aimed to investigat…