This study investigates the anti-inflammatory properties of Andaliman (Zanthoxylum acanthopodium DC.) fruit extract on inflamed human keratinocytes (HaCaT cells). The phytochemical profile of Andaliman reveals a high content of terpenoids from the Salkowski test, which inhibits the NF-κB signaling pathway, thereby suppressing pro-inflammatory cytokine production. The study demonstrates a s…
The skin is a vital outer layer that serves as protection. Once the protective layer is disrupted, for example the formation of wounds due to outer layer damage, it may increase the likelihood of contraction skin infection, which is a global burden. When open wounds are in contact with microorganisms, it allows attachment and proliferation, resulting in the development of biofilms. Antibiot…
Numerous health benefits of medicinal plants are attributed to the abundance of phytochemicals. Among these plants is Elaeocarpus grandiflorus, an endemic tree native to Southeast Asia. The locals utilize its leaves, fruit, endocarp, and bark to treat a variety of illnesses, such as acute intestinal inflammation, diarrhea, and urinary tract infections. This study aims to evaluate and quantif…
Breast cancer is the most common cancer in woman and the second leading cause of cancer deaths in the world among women. Research have shown the efiicacy of phytochecmicals as asupplementary treatment in breast cancer through the regulation of gene and microRNA (miRNA) expression. This study aims to identify differentially expressed miRNA-gene pairs in breast cancer across different stages in o…
The skin is a vital outer layer that serves as protection. Once the protective layer is disrupted, for example the formation of wounds due to outer layer damage, it may increase the likelihood of contraction skin infection, which is a global burden. When open wounds are in contact with microorganisms, it allows attachment and proliferation, resulting in the development of biofilms. Antibiotics …
Natural raw materials have been used for human health for centuries. Because of their distinct chemical composition and structure, wood and its bark are among the most important raw materials. The inner bark has a strong defense mechanism, which is supported by phenolic compounds and may contain a variety of antimicrobial agents that can be extracted and used as a food preservative. This study …
i3L is a life science higher education and research institute in Jakarta, Indonesia. Their Pharmacy department in the School for Life Sciences provides research project opportunities for students. This project aims to do phytochemical characterization of Marchantia paleacea, Pogonatum neesii, and Litsea oppositifolia extracts as a preliminary study for two bigger projects that aims to inves…
Since coronavirus disease 19 (COVID-19) was first found in China on 12 December 2019, finding potential treatments for this virus have always been pushed by many countries. The polyphenolic compound contained in Foeniculum vulgare seeds extract has been found to have antioxidant activity and is linked to the protection of diseases. Thus, the aim of this project is to perform extraction of Foeni…
Plants are widely used in the medicine field. As a tropical country, Indonesia has a wide variety of plants. One of the plants that can be used are Coriandrum sativum, which are found as a promising candidate for improving memory in patients with Alzheimer disease. This study has the aim to do phytochemical screening and antioxidant assays of the CS leaves. The phytochemical screening inclu…
“Kamlowelen” and “Kayu Bawang” are native papuan trees that have never been investigated before. Both tree barks are commonly used as a seasoning, tea, and medicine. In the present study, total phenolic content (TPC), DPPH assay, and phytochemical screening of tree barks extracted using five different solvents (Methanol, acetone, ethyl acetate, chloroform, and hexane) were analyzed.…
In the past 10 years, cancer research has been increasing and the discovery of new anticancer properties is targeted by the scientist. Medicinal plants are considered as the target for developing new anticancer drugs since it is more tolerable and has less side effects. Laportea decumana is one of the plants that grows in Papua, Indonesia. It has been used as the anti-fatigue and anti-stiff. It…