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An in vitro study of Pogonatum neesii antioxidant properties towards HaCaT cells
Reactive Oxygen Species (ROS) is a natural byproduct that plays many important roles for the body such as cell signaling, cell survival, and cell death. However, the accumulation of ROS can cause damage to the cell that leads to cell death and eventually to aging. To overcome that, various studies look for antioxidant substances, such as phenolic, flavonoids, and alkaloids. As the study of n…
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- BM 23-006
Peptidome Analysis of the SARS-CoV-2 Spike Protein across Variants
The continuing COVID-19 pandemic has brought to light how crucial it is to comprehend the SARS-CoV-2 virus and its proteins in order to develop efficient treatment and diagnostic approaches. However, there are difficulties with storage, processing, and analysis because of the enormous number of SARS-CoV-2 protein sequence data. In order to analyze SARS-CoV-2 data, this study examines the …
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- BI 23-007
The Adhesion Ability and The Effects of Probiotic Bacteria to The Presence of…
Lactic acid bacteria (LAB), which are mostly gram-positive bacteria, are frequently utilized in the food fermentation processes. In the last decade, LAB has been used in the development of probiotics to promote health and well-being by boosting the immune system and balancing gut microbes. An effective probiotic must have the capacity to adhere to human epithelial cells, and produce antimic…
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- BM 23-005
Prediction of T-Cell and B-Cell Epitopes From Protein Allergen Tropomysin Tha…
hellfish allergy is one of the highest prevalence allergies in the world, accounting for 7.7% of the population including Indonesia. Thus, the development of T cell epitope and B cell epitope based vaccines play an important role in future prospects for alternative treatment for allergy. The vaccine aims to induce the immune system so it will not react towards the allergen though the body al…
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- BM 23-004
The Comparison Between Logistic Regression and Convolutional Neural Network f…
"Multi-drug resistant tuberculosis (MDR-TB) is a disease caused by the Mycobacterium tuberculosis that could evade at least two different first-line anti tuberculosis drugs. MDR-TB poses a significant global health challenge, particularly in middle to lower income countries where affordable and rapid diagnostic tools are crucially needed. This situation has brought the idea of leveraging who…
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- BM 23-003
Understanding the Regulation of Proteasome Homeostasis upon Stress
Dysregulation of the ubiquitin-proteasome system (UPS) leads to the accumulation of aggregationprone proteins which has been linked to neurodegeneration and cancer. The 26S proteasome is acentral component of the UPS. It assembles by the successive recruitment of the 33 different proteasome subunits which is assisted by proteasome assembly chaperones: five for the CP and five for the RP. RPAC…
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- BM 23-012
Subchronic toxicity Study of Foeniculum Vulgare extract in Mice (Mus Musculus)
Herbal medicines are often used as therapeutic agents and contains one or multiple active compounds such as alkaloids, phenolics, and flavonoids. Flavonoids are natural compounds which are essential for pharmacological activity of plants and are known for antioxidant, antibacterial, and antiviral properties. As antiviral properties, Juglanin and quercetin are known to inhibit COVID-19 repli…
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- BM 23-013
Comparison of GWAS analysis pipelines using Hail/VariantSpark and PLINK on La…
Genome Wide Association Studies (GWAS) aims to find genomic variants that correlates with the occurrence of certain traits within a population. Various tools and algorithms can be utilized to conduct GWAS, among them are PLINK, Hail, and VariantSpark. In this study, a GWAS analysis pipeline was developed using PLINK, Hail, and VariantSpark to assess their performance in conduction GWAS asso…
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- BM 23-001
Novel Role of Pellino1 Ubiquitin Ligase in B Cell Lymphoma
Ubiquitination is a post translational modification (PTM) process that plays a role in protein degradation by the addition of ubiquitin groups to target protein. In the ubiquitination process, E3 ubiquitin ligase is responsible to mediate the bridge between E2 ubiquitin-conjugating enzymes and substrate for ubiquitin conjugation. Pellino1 or PELI1, one of the ubiquitin ligases, was found to …
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- BM 23-002
The Screening of Natural Autophagy-Inducing Compounds for Anti-Intracellular …
With the increasing concern about finding a different cure to overcome bacterial skin infections, this research aims to investigate the ability of the innate cell ability to decrease intracellular bacteria infection through autophagy. This study explores and decides several potential naturally-derived autophagy-inducing compounds to be applied to Escherichia coli-infected keratinocytes (HaCaT c…
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- BM 23-021
Anti-Aging Properties: The study of aging-related Genes on HaCat Cell Line Un…
Skin is the largest human organ which functions as the first barrier, which gradually ages over time and under stressful circumstances from the presence of ROS and finally results in skin disorders. Where the increased expression of the MMP-1 and COX-2 genes is one of the indicators of aging. Thus, a source of anti-aging is required. Natural sources with anti-aging characteristics are currently…
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- BM 23-019
The Effect of Freeze-Drying Parameters on Secretome Anti-Aging Potency In Vit…
The idea of anti-aging has become increasingly significant worldwide as people have begun to understand how aging impacts human health significantly. Currently, various synthetic anti-aging agents are available in the market. However, synthetic agents are often associated with several adverse effects. Hence, people are now looking for other alternatives. One of the candidates is secretome from …
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- BM 23-018
In Vivo Wound Healing and Antimicrobial Properties of Bio-Cellulose with Gree…
Diabetes is one of the most lethal and ninth most common diseases in the world, which is a metabolic disorder that causes a high and unusual blood sugar level due to the inability of the body to utilize sugar. Diabetes can cause multiple complications and damage to the system, one of them is diabetic foot ulcers (DFU). The most advanced treatment nowadays for DFU is by utilizing bio-cellulose, …
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- BM 23-022
The Evaluaon of An-aging Properes of Marchana paleacea Extracts Against ROS-i…
Aging is a universal phenomenon which affects all living organisms; a gradual degradation of form and function as the body succumbs to ever accumulating adverse changes. The skin is the largest and most superficial organ of the human body; as such it is exposed to external stressors which would increase the production of ROS, the primary actor of the aging process. As a response, the cell wi…
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- BM 23-009
The Role of Receptor Activity Modifying Proteins (RAMPs) in Pancreatic Cancer
Pancreatic Cancer (PaCa) is the 5th leading cause of cancer-related death in the UK. Understanding the signalling behind PaCa development is essential to create novel treatment for PaCa. RAMPs are family of single transmembrane domain proteins. The interaction between RAMP and GPCR give rise to AM receptor complex. AM is a hormone that has been shown to promote progression of various tumou…
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- BM 23-010
Optimisation of Crystal Formation for the recombinant Fungal Immunomodulatory…
Background: FIP-Lrh is a fungal immunomodulatory protein from Tiger Milk Mushroom with immunomodulatory and cytotoxic properties. Its biological properties can be further elucidated with the availability of a crystal structure. However, crystal structures from only four FIPs have been reported so far. As such, previous study at UCSI and MGVI on rFIP-Lrh crystallisation under two conditions …
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- BM 23-011
Investigation of Ethanol Miscible Calophyllum inophyllum Extracts (EME) Effec…
Topic Dermatitis (AD) is an inflammatory skin disease characterized by skin rashes and lesions. Downregulation or upregulation of various genes that contribute to the pathogenesis of AD makes it a complex disease. The main contributing genes are the skin barrier genes, FLG, IVL, and inflammatory genes, TSLP, TARC, IL-33, IL-25, MDC, and CTACK which are being investigated in this study. The curr…
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- BM 23-014
Restoration of X-ray Irradiation-Induced Intestinal Damage by Gut Microbiota
The gut microbiota determines the intestinal health status of the host by regulating gut epithelial and immune functions. Depletion of the beneficial gut microbiota after radiation exposure contributes to an exaggerated inflammatory response and dysregulation of intestinal epithelial cells. Previous studies demonstrated that administration of beneficial gut microbiota, Lactobacillus acidophilus…
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- BM 23-025
In Vitro Study of Litsea oppositifolia Stem Extract on the Keratinocyte HaCaT…
Litsea oppositifolia is one of the species found in Indonesia and its pharmacological effects have not been well studied. Therefore, the antioxidant activity of L. oppositifolia stem extract was evaluated in human keratinocytes (HacaT cells) under H2O2-induced oxidative stress through related gene expression. The ethanol stem extract of L. oppositifolia was screened initially for its antioxidan…
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- BM 23-024
Analysis of Wound Healing & Antibacterial Properties of Keratin-Immersed Bio-…
Diabetes has been categorized as the fifth highest mortality cause worldwide. The diabetic wound has an altered wound-healing mechanism which leads to longer inflammination stages and higher chances of infection. Hence, it causes chronic wounds. Because it is necessary to keep the wound moist and manage exudate, the wound dressing selections is essential in the management of the wound. Bacteria…
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- BM 23-016
Study of Itchy Leaf Extract as New Possible Antiviral Properties Against Newc…
Laportea decumana often known as itchy leaf, is a Papuan wild plant. Its antiviral activity was investigated for future recommendations of possibly new medication development, and the NDV virus was employed as a safe model for infection. To investigate the toxicity of itching leaves, a cytotoxicity experiment employing MTS was performed. Plaque assays were performed to evaluate the antiviral ac…
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- BM 23-023
Immunoinformatics Approach to a Multivalent and Multi-epitope Oral Vaccine De…
The currently available COVID-19 vaccine is thought to be sufficient in protecting against SARSCoV-2 infection, whilst the constant mutations of SARS-CoV-2 and the failure of the vaccine mto evoke protective mucosal immunity have remained problems. This condition has brought forward the idea of targeting nucleocapsid (N) protein as a more conserved region of SARS-CoV-2, in addition to the spike…
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- BM 23-035
Role of Integrated Stress Response in Mediating Mitochondrial Unfolded Protei…
The integrated stress response (ISR) is one of the most conserved cellular stress responses during mitochondrial dysfunction. The keys in the activation of ISR are the phosphorylation of eIF2α and subsequent induction of ATF4. The phosphorylation of eIF2α is caused by the activation of four specific serine/threonine kinases, which are Heme Regulated Inhibitor (HRI), Protein Kinase Ribonucleic…
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- BM 23-034
Method Development for Investigating SARM1 Post Translational Modification to…
Axon degeneration played a part in the development of neurodegenerative disease for instance Alzheimer’s diseases, chemotherapy-induced neuropathy, and traumatic brain injury. It is found that axon degeneration is present prior to the onset of symptoms. Therefore, scrutinizing the molecular mechanism is detrimental. Recently, it has been found that SARM1 NADase play a role in the developmenta…
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- BM 23-033
Validating hit genes from CRISPR screening on response toward combinations of…
Acute myeloid leukemia (AML) is a heterogenous blood cancer disease that develops from the stem cell precursors which the myeloid lineage happened due to genetic lesion that leads to overproduction and failure to differentiate these myeloid blast cells. A mutation in the FMS-like tyrosine kinase 3 (FLT3) gene, is the most frequent genetic lesion in AML patients, this mutation is linked with a p…
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- BM 23-031
Investigation of Antibacterial Activity of Hydrophilic and Hydrophobic Extrac…
Diospyros digyna is a wonderful fruit because of the fruit’s delicacy but not only that also because of how the fruit is easy to grow in most environments it can encounter and pest free mostly due to the effect of secondary metabolites called phytochemicals compounds. The study aimed to investigate the antibacterial properties of Unripe and ripe Diospyros digyna fruits against S. aureus and P…
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- BM 23-030
Investigation of Antibacterial Activity And Potential Anti-Inflammatory Prope…
Staphylococcus aureus is an opportunistic pathogen that commonly inhabits the human skin and can cause skin infection, especially in individuals with impaired immune systems when skin is damaged. Treatments usually involve the usage of antibiotics. However, antibiotic effectiveness is in danger due to the fast development of resistant microorganisms worldwide. As a result, there is a growing …
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- BM 23-026
The Effect of Notch Signaling In Hindbrain Serotonin Neurons Differentiation …
Serotonin (5-HT) neurons are currently of research interest since these neurons have a crucial role in regulating human homeostasis and psychological states. These neurons are generated from the hindbrain raphe nuclei and are classified into rostral (r1-r3) and caudal (r5-r8) groups. While rostral groups have been successfully developed, only a few functional caudal 5-HT neurons are available i…
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- BM 23-027
Investigation In The Role of Lamin B1 In The Development ofKidney Glomerulus
Lamins are the major component of nuclear lamina that have roles in several cellular processes, such as cell proliferation and cell survival. Especially lamin B1, which plays a role in maintaining mechanical support of the nucleus, is believed to be essential during embryo development for proper organogenesis. However, previous research has discovered the correlation between age-related kidney …
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- BM 23-028
Investigating Wound Healing Properties Of Centella Asiatica Extracts On Human…
Centella asiatica also referred to as Gotu Kola is a plant that has been utilized for hundreds of years in both traditional and modern medicine. In skin care products, it has been claimed that Centella asiatica leaf extract stimulates collagen production, reorganizes the damaged tissue, restores tissue firmness and skin elasticity, and improves the appearance of the skin. Triterpenoid compounds…
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- BM 23-029
Investigating the Effects of Litsea oppositifolia Stem Extract on HaCaT Cell …
Skin aging is an inevitable process in which the skin declines in quality which can be affected by intrinsic and extrinsic factors. One of the important factors contributing to skin aging is the accumulation of ROS (Reactive Oxygen Species). The ROS model was often used to study the effect of compounds that could affect skin aging and the most commonly used ROS model is H2O2, has been associate…
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- BM 23-017
Comparative Study of Umbilical Cord-derived Mesenchymal Stem Cells Secretome …
Skin anti-aging is a primary focus in derma cosmetics, targeting the reactive oxidative species (ROS) pathway for developing anti-aging therapies due to its role in the degradation of dermal extracellular matrix (EDM). Collagen type 1 is targeted to combat skin aging due to its role in preventing wrinkles formation and re-epithelization of human keratinocytes (HaCaT). Cell-free treatments have …
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- BM 23-015
The Effect of Pediococcus Acidilactici as a Starter on the Quality of Modifie…
Modified cassava flour (mocaf), is one of the cassava fermentation products using lactic acid bacteria. Mocaf is generally safe for people that have certain conditions due to its gluten-free. It also contains low-protein but rich in carbohydrates. Fermentation starter can affect the quality of mocaf. Pediococcus acidilactici has a potential as a starter for fermented food. Until now there is no…
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- BT 23-035
Embracing the Importance of Health Status Maintanance on Young Adolescents Ag…
Adolescent nutrition and health can improve by practicing healthy eating habits, engaging in regular physical activity, and maintaining good personal hygiene. A healthy breakfast and balanced diet can help teens focus better in class, build strong bones and muscles via regular exercise, and improve their self-worth and physical cleanliness through good personal hygiene. Teenagers in Indonesia a…
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- EP FS013
The Breeze Project : Supplier Quality Improvement Program
Food quality is an important aspect to be upheld especially for big companies whose end consumers are babies, such as Danone. Danone or every other company has their own standard of product quality which has to be constantly maintained by everyone in the value chain, including suppliers. However, suppliers’ performances—which consequently affect the company as well—are not always satisfac…
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- EP FT037
In Silico Study of Plant Bioactive Compound of Coriandrum Sativum Against Gab…
Cognitive impairments in thinking are the example of neurodegenerative diseases that happened in Alzheimer Disease (AD). Short memory loss (dementia) is one of the symptoms, showed by 60-70% cases found and gradually progress in declination of thinking. Therefore, dementia usually is associated in AD. Lately, an inhibitory neurotransmitter called GABA is known for its relation with working memo…
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- EP BI004
Algorithm Development of PVS (Premature Ventricular Contraction) Detection Sy…
Cardiovascular diseases are one of the most prevalent non-communicating diseases, and also one of the leading causes of death globally. In Indonesia alone, cardiovascular diseases are one of the leading causes of death. However, many people are still unaware about the early prevention and mitigation of cardiovascular disease, increasing the prevalence of the diseases. The innovation of self-dia…
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- BT 23-033
Postbiotics Fed Nile Tilapia (Oreochromis Niloticus) Against Aeromonas Hydrop…
Nile Tilapia (Oreochromis niloticus) is a notable species reared in the aquaculture industry. It is famous for its protein content, rapid growth rate and adaptability in various types of water. It makes Tilapia advantageous in aquaculture for mass production through intensification. However, the stack volume of rearing may lead to disease manifestation by bacteria, fungi, parasites, and viruses…
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- BT 23-032
Sensory Profiles and Acceptability Determination in Different Concentrations …
Cocoa is widely used as a raw ingredient in both confectionery and non-confectionery products in the food industry. In the food industry, the most commonly used cocoa derivatives product is cocoa powder. In this project, cocoa powder would be used as one of the ingredients inside the chocolate cream filling. There would be one control sample and three prototypes of cream filling with the reduct…
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- FS 23-010
The Effect of Pasteurization and Sterilization Process Against the Physicoche…
PT Takasago International Indonesia is a company that produced flavors and fragrances. Takasago has two sites, which are headquarter and production site in Indonesia. Headquarter site is responsible for handling and managing the customer request, meanwhile production site is responsible for producing flavor and fragrances product. One of division in the headquarter site is sweet application div…
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- FT 23-038
Separation of Natural Folic Acid from Fermented Nixtamalized Corn Using Rhizo…
Folic acid is an important vitamin for fetal development and nucleotide and amino acid metabolism. Corn is one of the good sources for folic acid while tempeh fermentation has been reported to increase folic acid content. To concentrate further, membrane filtration is a promising technology. This study aims to understand the effect of microfiltration conditions towards the increase of folic aci…
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- FS 23-013
The Use of Keratin-Biocellulose Black Tamanu Oil Hydrogels as A Novel Wound D…
Diabetes mellitus is a global health issue that is gaining traction in our healthcare system which leads to impaired wound healing and results in chronic ulcers, these increases the risk of amputation and disease mortality rate by 50-59% in 2020. Therefore, better inventions to treat diabetic ulcers are required. A bio-cellulose hydrogel is a form of wound dressing that can aid in protecting t…
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- BM 23-020
Acceptability Evaluation of Pigeon PEA (Cajanus Cajan) Sweet Soy Sauce at PT …
Soy is a widely popular seasoning in East and Southeast Asian Cuisine, traditionally made by cooking soybeans and inoculating them with Aspergilius sojae yeast for five-day fermentation period, followed by brining. This project aimed to explore the potential of pigeon pea (Cajanus cajan) as a subtitute for soybean in the production of sweet soy sauce. Both soybean and pigeon pea sweet soy sauc…
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- FT 23-037
Substitution of Commercial Pectin with Lemon Pectin in Production of Raspberr…
In the attempt of reducing fruit waste from fruit industry, thawed fruit and lemon waste (peel and pith) can be utilized to produce jam. Pectin, a vital gelling agent in jam making is abundant in lemon waste, however, its yield and effectiveness depends on the extraction method. In this study, the lemon pectin was extracted from using heat and strained with cheesecloth. The pectin was then adde…
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- FT 23-042
Determination of The Factors Affecting Shrinkage Packaging Issue: Verificatio…
Packaging plays an important role in maintaining product quality. Some of packaging's basic functions are containment, protection, communication, and convenience. As a communication function, it not only provides basic information about the product, but also as a commercial purpose to attract customers. However, some cases might happen in the development of visual defects of packaging which red…
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- FT 23-036
Evaluation of Bacillus subtilis P5-6 as Protective Culture in Traditional Bac…
Back slopping is referred to as the small inoculation of a previous successful fermentation product to the raw material, as the starter culture. One example of the traditional fermented product that utilizes the back-slopping methods is dadih. As it is an artisanal product that is made using traditional methods that involve humans and is prone to contamination, such as Staphylococcus aureus…
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- FS 23-001
Millennial and Gen Z Acceptance Towards Green Marketing Advertisement of Body…
In recent years, a number small and medium-sized businesses selling eco-friendly and sustainable products in Indonesia have started as the result of increasing demand from generations Y and Z. Known for their “digital savvy” attitude and synonymous with social media usage, many of these businesses use social media sites,such asInstagram, to initiate “green marketing” activities promotin…
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- MBM 23-001
Develop a Branding and Marketing Strategy for Slimming Tea Product in Indones…
The market of slimming tea has grown significantly in recent years as a result of rising demand for natural and organic products on growing awareness of the importance and maintaining a healthy lifestyle. This broad industry offers a range of slimming tea products, from conventional blends to specialty formulas created to meet particular health objectives. Consumer opinions on slimming tea vary…
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- MBM 23-003
Factors that Influence Consumers Purchase Intention Towards Natural Lipsticki…
In recent years, beauty companies have become one of the most succesful business in the world. The cosmetic products are already being produced with advanced technology that can create various new cosmetics products each year. However, the ingredients inside cosmetic formulations become main concerns to many consumers for health concerns, which make natural products in high demand. This study w…
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- MBM 23-004
Acne Prone Skin Consumers Toward the Importance of Moisturizers and The Types…
Acne, also known as acne vulgaris, is a chronic inflammatory illness that affects the sebaceous glands and is characterized by the production of erythematous nodules, pustules, and papules, which can scar. Acne is the eighth most prevalent disease, estimated to affect 9.4 % of the global population. Specifically in Indonesia, the prevalence of acne is increasing year by year. Acne has affected …
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- MBM 23-002
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