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Screening of Isoflavone-Modified Compounds as Potential Therapeutic Agents to…
inflammation plays a crucial role in the pathogenesis of various skin conditions such as psoriasis and atopic dermatitis, primarily driven by abnormal cytokine production. This study investigates the anti-inflammatory potential of several synthetic isoflavone-modified compounds (CYR-6811k, CYR-6812l, CYR-6813m, CYR-6815o, CYR-6816p) by examining their effects on cytokine production in THP-1 …
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- BM 24-038
Characterization of meso-Dihydroguaiaretic acid (MDGA) derivative as an anti-…
Inflammation is a crucial part of the immune response, involving neutrophils, the predominant white blood cells, in combating pathogens. Their recruitment is regulated during inflammation, which can lead to conditions like autoimmune diseases and cancer. This study aims to explore meso- Dihydroguaiaretic acid (MDGA) derivatives, particularly MZ47, as potential therapeutic options for neut…
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- BM 24-001
Side Effect Of Vigabatrin As An Anti-epileptic Drug Observed In Mouse Model
Infantile spasm is a type of epilepsy that occurs in infants that is characterized by the sudden movement throughout the whole body. It is crucial to detect the disease and undergo suitable treatments as soon as possible in order to minimize the potential negative long-term effect in learning development. One of the most effective treatments is the usage of anti-epileptic drug Vigabatrin that i…
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- EP BT-009
Screening Of Potential Compound For Psoriasis Drug Development: Cell-based Study
Psoriasis is the most common type of chronic inflammatory skin disease clinically characterized by a scaly erythematous eruption in the epidermal skin, primarily caused by the interaction of immune cells and keratinocytes that induces inflammatory skin response. Psoriasis is best characterized as a complex, multifactorial disorder, where both genetic and environmental factors play crucial roles…
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- EP BT-010
Anti-inflammatory Properties Of Fermented Cassava (cassava Tape) Aqueous Extr…
Inflammation plays an important role in the body as a defense mechanism against pathogens, toxins, and dead cells. However, when the infection continues and inflammation becomes unregulated, acute inflammation eventually progresses into a chronic one, which holds responsibility for numerous chronic non-communicable diseases such as cancer, hypertension, diabetes, etc. various foods have bee…
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- EP FS-002
Exploring the Role of Endoplasmic Reticulum Stress in Macrophage Polarization…
Exposure to harmful stimuli could induce tissue damage. Failure to remove the harmful stimuli and to repair its resulting damages is associated with increased level of ER stress, which is also closely associated with development of age-related diseases including cancer and metabolic diseases. Additionally, chronic inflammation, characterized by the imbalance of M1/M2 macrophage ratio, is al…
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- BM 23-008
Inflammatory Evaluation of a topical Moisturizer Product on Human Keratinocyt…
Skin barrier disorder is a condition whereby the skin is incapable of preventing the penetration of exogenous stimuli. As a result, inflammation are also elevated in an effort to eliminate these materials, resulting in increased sensitivity towards exogenous material. Treating this dysfunction can be achieved using topical application of prescriptions such as moisturizers that can tone down…
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- BM 22-006
Nerve Sedation Effect of a Sensitive Skin Moisturizer towards Human Keratinoc…
Sensitive skin, which can be indicated by unpleasant feelings to the skin, such as burning, tingling, stinging, and itching, has become a growing concern in the last few decades. This situation is mainly due to the increasing level of air pollution, global warming, and the use of skin products that can trigger and worsen sensitive skin conditions. To tackle this problem, numerous products have …
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- BM 22-050
ANTI-INFLAMMATORY EFFECT OF CALOPHYLLUM INOPHYLLUM SEED EXTRACT ON LPS-INDUCE…
Calophyllum inophyllum Lin has been used as folk medicine for various health problems which has been demonstrated to be a potent anti-inflammatory agent, including atopic dermatitis. In this study, the anti-inflammatory activity of C. inophyllum seed extract was evaluated in LPS-induced HaCaT cells as an atopic dermatitis model. C. inophyllum seed was extracted with ethanol, followed by separat…
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- BM 21-006
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