Non-Small Cell Lung Cancer (NSCLC) is a prevalent and highly deadly form of cancer that affects a significant number of individuals worldwide. The rise in the number of smokers has correspondingly led to an increase in the incidence of NSCLC. Furthermore, even if smokers were to quit, it would not lead to a reduction in the severity of NSCLC. A549 is an immortalized cell derived from NSCLC …
The study addressed the global health concern surrounding folate deficiency by proposing the development of folate-enriched natural snacks using osmotic dehydration, due to its potential to fortify fruits with essential vitamins. The study was structured into preliminary and primary studies. In the preliminary study, a variety of fruits were assessed, and guava was selected as the most suit…
Pickering emulsions using solid particles to stabilize emulsions are common in the food industry. By-products like rhizome pomace from the herbal beverage jamu are often discarded despite containing valuable compounds. Kaempferia galanga L. (aromatic ginger or kencur) is widely used in jamu Beras Kencur for its health benefits. This research focused on the valorization of aromatic ginger by…
In modern times, consumers are increasingly choosing food packaging that is high quality and sustainable to ensure the safety of the food and minimizing the use of non-recyclable materials that cause negative impact on the ecosystem. As a result, edible film is becoming more popular to improve the quality and safety of food. 3D printing technology offers excellent capability and potential in…
Lung is vital to the intricate maintenance of oxygen and carbon dioxide exchange which is regulated by specialised cell lineages. This regulation involves tight coordination of epithelial cells regulated by Non-Muscle Myosin II (NM II). Although adult lung cells are typically quiescent, Acute Lung Injury (ALI) may disturb the homeostasis and cause loss of airway epithelial layer. This will c…
Pancreatic adenocarcinoma (PAAD) remains a life-threatening disease with the most unfavorable prognosis among all cancer types. This is mainly due to the high rate of cell survivability marked by rapid cell proliferation and migration activity. Despite having KRAS oncogene as a known commonly mutated driver gene, targeting it has been challenging and has hindered the development of effective…
Human Immunodeficiency Virus (HIV) is a retrovirus responsible for causing acquired immunodeficiency syndrome (AIDS). The pol gene of the HIV genome encodes protease and reverse transcriptase, and integrase region which is responsible for viral infection and survival inside the host cell. Antiretroviral Therapy is usually administered to target these regions due to their significance in vir…
Bread is widely favoured food due to simple composition and convenient suitability for daily consumption. One of the main ingredients used to determine the bread quality is yeast. As the Indonesian bread industry has grown, bread is being processed by replacing instant yeast with natural yeast because of increasing consumer interest natural products. Natural yeast is obtained from fermented…
Arak, a traditional Indonesian spirit typically produced from rice or sugarcane, is made by fermenting rice or fruit juice followed by distillation. This research explores using snake fruit (Salacca Zalacca var Pondoh) as an innovative raw material for Arak production, offering a novel flavor profile and creating a niche market. Snake fruit, containing fermentable sugars, presents a cost-eff…
Diabetes mellitus (DM) is a metabolic disease where insulin production and/or action is defective, leading to a chronic high blood sugar level (hyperglycemia), in which the highest type is type 2 diabetes mellitus (T2DM). Some of the pharmacological treatments are metformin and sitagliptin where the combination treatment of them provides more effects compared to the monotherapy. An imported…
Background. Next Generation Sequencing (NGS) is a technology that possesses tremendous potential in advancing precision medicine in oncology. However, in Indonesia, the progress of its integration remains hampered. This research is conducted with the hope of providing exploratory research for the general NGS maturity in Indonesia, its current level of implementation, and future challenges f…
Personalized medicine helps make decisions about illness prevention, diagnosis, and therapy based on a person's genetic profile. To use personalized medicine, genetic testing using Next generation sequencing (NGS) performed to determine the best drugs to treat the diseases. Cancer can be treated using personalized medicine. Each year, the number of cancer patients is rising, and with person…
Lung cancer, among all types of cancer, leads first in cancer incidence and accounts for the first largest source of cancer-related mortality worldwide in 2022. Such a high incidence and mortality rate is primarily due to the majority of patients being diagnosed with advanced stages of cancer. Chemotherapy remains a primary option for metastasized NSCLC, however, chemotherapy still possesse…
Green supply chain management has been a popular approach for many businesses to respond to many environmental issues, such as climate change, loss of biodiversity, resource depletion, greenhouse emissions, and climate change. This research aims to explore the effects of supply chain management on organizational sustainability performance and how it affects the products produced by the manu…
Photorhabdus insect-related toxins A and B (Pir A and Pir B) are two different types of insecticidal toxins that were firstly found in Photorhabdus luminescens. Its homolog, from Vibrio parahaemolyticus, is found to cause acute hepatopancreatic necrosis disease (AHPND) in the shrimp, since it contains plasmid pVA1. When binded together, Pir A and B can exert its effect, because they form a stru…
The Deleted in Liver Cancer family houses the RhoGAP proteins DLC1 and DLC2, which have already been known for their tumor suppressive capabilities, and DLC3, whose studies regarding this gene are minimal. This study seeks to elucidate the function of DLC3 protein towards tumor development by looking at the changes in angiogenesis and cell migration rate following DLC3 downregulation, using zeb…
This internship program at PT Ramuraga Tirta Lestari aimed to optimize and improve various aspects of kombucha production, including food safety, data organization, and production efficiency. The intern worked on several projects to achieve this goal, such as calibrating pH meters to ensure accurate measurement of acidity levels in kombucha, sterilizing bottles to prevent contamination and main…
An expensive Vanilla planifolia Andrew. Var. Vania 2 is commonly propagated using a stem cutting technique which is associated with low propagation rate. A method of callus regeneration was assessed in this experiment to increase the yield of vanilla plants by utilizing different concentrations and combinations of BAP and NAA supplemented into the MS media. The objectives of this experi…
The COVID-19 global pandemic caused by SARS-CoV-2 has been going on for almost two years and has negatively impacted the global population. The same as other viruses, SARS-CoV-2 is continuously mutating to adapt to the environment, and this may result in negative impacts, such as an increase in virus transmission, virulence, and even resistance to vaccines. Hence, questions regarding whether th…
The author was doing an internship at PT. Alamii Natura Sejahtera as a research and development intern for 6 months starting from July 2023 – January 2024. The author has several responsibilities including doing research for both optimizing existing product production processes as well as new product development. Additionally, the author also helps the team with the document-making for BPOM-r…
The overarching goal of this project is to comprehend the intricate dynamics of RNA viruses, specifically influenza A viruses, enteroviruses, and coronaviruses, which pose significant health threats. The focus lies in exploring hostvirus interactions, particularly the roles of host components in various stages of viral RNA replication, aiming to identify potential targets for antiviral interv…
Axon degeneration played a part in the development of neurodegenerative disease for instance Alzheimer’s diseases, chemotherapy-induced neuropathy, and traumatic brain injury. It is found that axon degeneration is present prior to the onset of symptoms. Therefore, scrutinizing the molecular mechanism is detrimental. Recently, it has been found that SARM1 NADase play a role in the developmenta…
Modified cassava flour (mocaf), is one of the cassava fermentation products using lactic acid bacteria. Mocaf is generally safe for people that have certain conditions due to its gluten-free. It also contains low-protein but rich in carbohydrates. Fermentation starter can affect the quality of mocaf. Pediococcus acidilactici has a potential as a starter for fermented food. Until now there is no…
Folic acid is an important vitamin for fetal development and nucleotide and amino acid metabolism. Corn is one of the good sources for folic acid while tempeh fermentation has been reported to increase folic acid content. To concentrate further, membrane filtration is a promising technology. This study aims to understand the effect of microfiltration conditions towards the increase of folic aci…
Cervical cancer is the fourth most prevalent cancer and is the primary cause of mortality among women on a global scale. It is deadly once metastasize and therefore its early detection and prevention of its metastasis was crucial for the survival of the patient. Treatment targeting the prevention of metastasis was a necessity. Laportea decumana is a plant which has been shown to possess anti-ca…
The deep-sea ecosystem is a largely unexplored environment with unique chemical and physical conditions that impact the organisms living there. Deep-sea sediments contain a diverse population of electroactive bacteria (EABs) that have the potential to generate electricity in microbial fuel cells (MFCs). This study aims to investigate the influence of salinity concentration on bacterial viabi…
The increasing global electricity consumption driven by population growth and industrial development necessitates the exploration of environmentally friendly renewable energy sources. Microbial fuel cells (MFCs), more specifically deep-sea sediment microbial fuel cells, have gained significant attention in the bioenergy industry as they can harness bacteria capability to generate electricit…
Erythropoietin is a glycoprotein hormone produced by the kidney, which triggers the formation of red blood cells in the bone marrow. However, due to chronic kidney disease, the erythropoietin hormone is insufficiently produced in anemic conditions. Hence, a therapeutic recombinant human erythropoietin (rhEPO) is the alternative way to overcome chronic anemia. Genetically engineered host cells,…
Syzygium aromaticum, commonly known as cloves, is considered as one of the richest dietary sources of antioxidant and polyphenolic compounds. The bioactivity and antimicrobial activity of this spice is enhanced by using novel extraction techniques such as ultrasound-assisted extraction (UAE). Sample-to-solvent ratio is one of the important factors that impact the functional properties of pl…
Strawberries are known for their vibrant color, juicy texture, and enticing sweetness, which may change as they ripen. A freeze-drying (FD) process was used to alter the changes. However, because FD is a time-consuming process, a pretreatment process is essential for accelerating the FD process. This research aims to improve the FD process for strawberries by using osmotic dehydration (OD) a…
Food seasoning powder which are used as and/or within food products should have free-flowing properties. Powder caking is one of the adverse effects of seasoning powder with poor free-flowing properties. A solution to prevent powder caking is by improving the composition of the seasoning powder. It can be achieved by substituting the liquid-based to powder-based ingredients and/or utilization o…
Pediococcus acidilactici is a lactic acid bacteria that has been found on many fermented foods around the world, showing its capability as a starter culture. It is gaining research interest due to its probiotic potential that can provide additional health benefits, further increasing its value as starter culture. Starter cultures are typically commercialized in powder form, with one of the …
Erythropoietin is a glycoprotein hormone produced by the kidney, which triggers the formation of red blood cells in the bone marrow. However, due to chronic kidney disease, the erythropoietin hormone is insufficiently produced in anemic conditions. Hence, a therapeutic recombinant human erythropoietin (rhEPO) is the alternative way to overcome chronic anemia. Genetically engineered host ce…