White and sweet bread consumption in Indonesia grew to 3.01 kg/capita/year in 2020. This surge is due to bread's ease of preparation and consumption. Bread is a food product composed of wheat flour, water, sugar, salt, butter, and yeast. Yeast that is used to make bread is frequently dry yeast or instant yeast. Saccharomyces cerevisiae is the primary yeast in bread making. Natural yeast, de…
Negative effects on meat consumption have prompted the rise of protein alternatives. Although chicken is rich in protein, it has no dietary fibre. Hence, alternative fibre and protein-rich ingredients can be found in shiitake mushrooms with an umami flavour and tempeh with a dense texture. High-pressure processing (HPP) can improve the texture and technological functionalities of various foo…
Excessive meat consumption's negative effects have driven the development of meat alternatives. While chicken is protein-rich, it lacks fiber, so mushrooms were used for their high fiber content, and jackfruit's fibrous texture to mimic chicken. High-pressure processing (HPP) improved texture and preserved nutritional value. This study aimed to develop nuggets using chicken, hybrid, and PBM…
Bread is widely favoured food due to simple composition and convenient suitability for daily consumption. One of the main ingredients used to determine the bread quality is yeast. As the Indonesian bread industry has grown, bread is being processed by replacing instant yeast with natural yeast because of increasing consumer interest natural products. Natural yeast is obtained from fermented…
Arak, a traditional Indonesian spirit typically produced from rice or sugarcane, is made by fermenting rice or fruit juice followed by distillation. This research explores using snake fruit (Salacca Zalacca var Pondoh) as an innovative raw material for Arak production, offering a novel flavor profile and creating a niche market. Snake fruit, containing fermentable sugars, presents a cost-eff…
Diffuse Intrinsic Pontine Glioma (DIPG) is a malignant tumor found in the brain stem which mainly affects children. It has an aggressive nature with no available curative treatment. Cancer immunotherapy using specific tumor antigens to target tumor cells may be a viable alternative therapeutic option for DIPG, however antigen presentation is highly downregulated in tumors. This study aims t…
Paediatric cancer accounts for the majority of cancer-related mortality in children. Although current treatment increased the overall survival rates, young individuals often encounter life-long side effects from toxic therapies. Therefore, there is an urgent need for targeted therapies aimed at tumour-specific vulnerabilities for greater specificity and reduced toxicity, in which precision m…
Mycoproteins, that are produced through filamentous fungi fermentation, have gained popularity because of their rich protein content and sustainability as an animal-based protein alternative. However, the cost of the commerciallized mycoprotein exceeds the cost of regular meat. Therefore, scientists are exploring various inexpensive substrates and GRAS fungal strains with high survivability …
Glioblastoma (GBM) is known as a highly aggressive and malignant form of brain cancer. Despite advances in understanding the genetic and molecular basis of glioblastoma, it has a poor prognosis with a median survival rate of 9 months. The complex interplay between malignant cells and the surrounding tumor microenvironment (TME) plays a pivotal role in tumor progression and treatment respons…
This study focuses on the characterization of bacterial communities in Takakura compost specifically applied to Saga plants. Takakura compost, known for its simplicity, cost-effectiveness, and efficacy in producing high-quality compost, utilizes the natural processes of microorganisms to break down organic materials. The research involves the analysis of bacterial communities during the comp…
Indonesia is striving for a greener and cleaner future, and is pushing for the commercial application of biofuels. Currently Indonesia is focused on palm-oil based biofuels, but it comes with many negative impacts and challenges. Hence, it is necessary to improve upon biofuel production technology. Shifting towards third generation microalgal biofuels is an attractive option, as microalgae h…
Bacterial cellulose (BC) is a promising packing material as it is biodegradable, non-toxic, has good mechanical properties, and can form bonds with foreign particles. Meanwhile, P. acidilactici postbiotics (metabolites) have the potential to be a natural food preservative as they contain antimicrobial compounds that are heat- and pH-stable. This research aims to develop a novel antimicrobia…
Compost has an important ecological role in increasing soil fertility, plant growth and sustainable agriculture, especially in recycling organic waste. This research characterizes the role of Plant Growth Promoting Fungi (PGPF) derived from Takakura compost and analyzes the influence of microbial communities on saga plants (Abrus precatorius). Takakura Compost is an alternative because of i…
Psoriasis is a prevalent chronic autoimmune inflammatory skin disease affecting over 125 million individuals globally, posing a significant health challenge. Investigating synthetic compounds featuring the 1,2,3-triazole structure known for their anti-inflammatory effects, this research aimed to evaluate synthetic drug compound candidates for their anti-inflammatory properties. The assessmen…
Hydroponic cultivation has emerged as a cost-effective alternative to traditional soil-based agriculture and may be less susceptible to pests and diseases. They can be set up in controlled environments, making them suitable for year-round production in urban areas with limited land availability. EM4 is a type of fertilizer that can increase agricultural systems' decomposition, composting, a…
Abrus precatorius, colloquially known as the Saga plant, produces various secondary metabolites with valuable pharmaceutical properties such as glycyrrhizin and abrusoside. Methyl jasmonate (MeJA) is a phytohormone known to regulate the expression of the MYC2 transcription factor, which in turn promotes the biosynthesis of secondary metabolites in plants. Understanding the resolution to enh…
Overproduction of plastics and difficulty to degrade the plastic have become one of the major threats in the environmental sector. This plastic has been reported to accumulate in many different places. Many methods have been used to solve the problem but resulting in other harmful effects toward the environment. Methods by utilizing the enzyme from microbes can be feasible to perform withou…
Abrus precatorius, known as Saga, is a legume plant belonging to the tropical Asia region that is known for its toxicity. Precedent research has shown that Abrus precatorius leaves and roots have a potential effect on treating various diseases such as cough, bronchitis, hepatitis, and cancer. However, Saga plants are being undervalued in Indonesia due to the lack of knowledge on the benefit…
Wound dressings play a crucial role in promoting efficient wound closure and healing by providing an environment conducive to tissue repair. Traditional wound dressings, such as cellulose-based gauze, often exhibit challenges in adhesion and exudate absorption, necessitating frequent replacements that may cause additional trauma. Biocellulose (BC), derived from bacteria, presents a natural c…
Aquaculture industries are evolving rapidly to meet the escalating global demand for seafood as the human population grows. Enhancing the nutritional quality of feed for aquatic animals, such as fish larvae, is critical for increasing seafood production sustainably. Live feed, particularly copepods (crustacean zooplankton), has emerged as a preferred alternative to conventional synthetic fee…
Abrus precatorius is a plant highly valued for its foods and medicinal benefits, notably due to the triterpenoid saponins that it can synthesize. The triterpenoid saponins produced are glycyrrhizin in the roots and abrusoside in the leaves. However, the yield of triterpenoid saponins in A. precatorius is low. To increase the yield, it can be induced by activating the stress condition for the…
Sacha Inchi is a plant which is best known for its medicinal properties and a food source. However the husk and the shell usually ended up as waste. As a result, this research aims to valorize the Sacha Inchi Waste as feed to grow Black Soldier Fly Larvae. In this experiment, 100 Black Soldier Fly Larvae were hatched in a container and after 5 days, feed made of press cake waste of Sacha In…
Pediococcus acidilactici is a gram-positive lactic acid bacteria (LAB) widely used as a probiotic due to its safety, benefits, and ability to survive in the harsh environment of the gastrointestinal (GI) tract. One of the challenges for probiotic species is the presence of bile salt, which can degrade bacterial cell membrane due to its main function in lipid solubilization. Bile salt can als…
As the human population grows, the demand for organoleptic properties in food has linearly increased, including the use of harmful synthetic colorant. Therefore, carotenoids, as a secondary metabolites and natural compounds, can be used as an alternative to natural food preservatives. They are also attributed to antioxidant properties which are beneficial for human consumption and health. T…
Obesity, characterized by excessive adipose tissue, is linked to adverse health effects. Ginger, containing compounds like gingerol, shogaols, and zingerone, exhibits anti-cancer, anti-inflammatory, anti-diabetic, anti-hepatic steatosis, and antioxidant properties. Turmeric has potential as an anti-adipogenic agent by suppressing key regulators of adipogenesis. This study analyzed the anti-adi…
Bacterial cellulose (BC) is a biopolymer currently being coveted for its versatility, sustainable sourcing and biodegradability. The Indonesia International Institute for Life Sciences (i3L) lab has been conducting research on BC fermentation and surrounding BC produced by the kombucha isolate Komagataeibacter intermedius, with past findings showing a great prospect of the bacteria being abl…
Erythritol is a beneficial sugar alcohol that can be used as a sugar substitute for diabetic patients. It has 0.2 kcal/g calories and still has 70-80% sweetness with the widely used sucrose. Erythritol production through extraction and chemical synthesis is ineffective due to the small product yield, making the commercial production expensive, so alternative synthesis using biotechnology is …
The therapeutic benefits from the utilization of the roots and leaves saga plant have been known to Asian cultures for centuries. Numerous studies have attributed the therapeutics properties to triterpenoids, a class of secondary metabolites found in plants that are produced by the plant defense system under stressful environmental conditions. Recent study in legume model plant, lotus japon…
Obesity, a longstanding global food security issue, has increased in Indonesia since the COVID-19 pandemic due to higher consumption of high-fat, high-sugar foods and more sedentary activity during quarantine. Prevention of obesity can be achieved from the molecular phase through treatment with spice extract, like cinnamon, to mouse 3T3-L1 preadipocytes. The bioactive compound present in ci…
Soy flour is a good source of vegetable proteins, with a low fat content. Sorghum has proven to be a super-rich component of nutrition and adds a superb flavor to gluten-free baking. The project aims to expand the age range by product development of soy sorghum biscuits that are edible at the age of 3 to 5 years by adding chocolate flavors. The study examines the effect of cocoa powder addi…
Emulsifying salts, such as trisodium citrate (TSC), disodium phosphate (DSP), and sodium hexametaphosphate (SHMP), are crucial for improving the texture and sensory characteristics of processed cheese slices. These salts work by binding calcium ions and altering the protein structure, which enhances the cheese's firmness, ability to melt, and moisture level. Trisodium citrate (TSC) is known…
Black sapote is an underutilized fruit with various bioactive compounds and medicinal properties. To increase its utilization and value, the black sapote was turned into kombucha and spray-dried to increase the shelf life and stability of its active components. Encapsulating agents are used to protect the bioactive compounds during spray drying. This study investigated the effect of ferment…
Pasta is one of the most popular staple foods for many consumers. Colored pasta has emerged as a creative approach to improve product appearance. Red Fruit Oil (RFO) (Pandanus conoideus Lam) can serve as natural colorants with potential health benefits. Encapsulation method using spray drying was applied to RFO to lower the susceptibility and mask unpleasant sensory profiles. This project a…