Celiac disease is a gluten-related disorder that is triggered when a person consumes gluten. This will cause the immune system to attack the tissue. This problem has caused society to demand more gluten-free foods, including cakes. However, gluten-free cakes have several challenges in that their texture is denser than wheat flour cakes. In this study, gluten-free cakes will be fortified with da…
Enzymatic hydrolysis can overcome the problem about the quality of the instant porridge. The process was divided into 3 steps, gelatinization, liquefaction, and saccharification. The glycosidic chain will be broken down by the amylase and turn the starch into a maltose and glucose that gives natural sweetness and better mouthfeel. Hydrolysis really depends on the temperature as the enzyme might…
PT Sinar Sosro is the world's first company that develops ready-to-drink beverages in packed bottles. The company's primary activity is to manufacture and distribute RTD beverages, mostly tea-based products, to both the domestic and foreign markets. Tea is one of a few plantation commodities that is a mainstay of Indonesia's global market. One of the most important factors to consider while mak…
Tea consumption in Indonesia is on the rise including Ready to Drink (RTD) tea. TehBotol Sosro is the one of the popular ready-to-drink (RTD) tea brand in Indonesia. Tehbotol Sosro is famously known for not having preservatives in its beverages. It only consists of water, tea, and sweetened with sugar and contains no artificial ingredients. The physicochemical properties, such as pH, brix level…
Increasing demand as well as interest for plant−based ingredients such as konjac was occurring. Additionally, in order to stabilize the prices, extend shelf life, and enhance added value of peaches, various processing methods and products must be developed. White peach has a good insight from the market due to its premium imported fruits that can't be cultivated in Indonesia. However, in this…
Staphylococcus aureus (SA) is an opportunistic human pathogen that can cause infections in humans, including atopic dermatitis, also known as eczema. Eczema is a skin condition where patients experience flare-ups characterized by redness, itchiness, dried skin, and may vary among individuals. Interestingly, there is a common pattern where all eczema patients' skin is colonized by SA, and treatm…
Sarcopenia, an age-related disease where loss of muscle and strength progresses, has become a research interest for scientists over the past few decades. Sarcopenia in and of itself can cause physical incapacity, functional impairment, and even death to patients. Research has shown that mitochondrial dysfunction has been known to cause sarcopenic muscle tissue damage. Furthermore, recent studie…
Hepatitis C Virus (HCV) remains a significant global health threat, contributing to chronic infections and hepatic complications, including hepatic steatosis and hepatocellular carcinoma (HCC). This study investigates the intricate relationship between HCV and fatty acid metabolism, focusing on lipid droplet accumulation and the impact of HCV on fatty acid synthesis genes. Utilizing an HCV-infe…
Infantile spasm is a type of epilepsy that occurs in infants that is characterized by the sudden movement throughout the whole body. It is crucial to detect the disease and undergo suitable treatments as soon as possible in order to minimize the potential negative long-term effect in learning development. One of the most effective treatments is the usage of anti-epileptic drug Vigabatrin that i…
Polyascus planus is a parasitic barnacle (rhizocephala) in various crustacean hosts, including Metopograpus thukuhar, that can manipulate the host’s hemolymph ecdysteroid level. Ecdysteroid is an essential hormone for molting and reproductory development in arthropods which includes both rhizocephalan and crustacean. The manipulation allows the parasite to reproduce securely while it stays wi…
Psoriasis is the most common type of chronic inflammatory skin disease clinically characterized by a scaly erythematous eruption in the epidermal skin, primarily caused by the interaction of immune cells and keratinocytes that induces inflammatory skin response. Psoriasis is best characterized as a complex, multifactorial disorder, where both genetic and environmental factors play crucial roles…
Currently, the demand for sustainable platforms to address environmental problem is arising. Biodiesel is an eco-friendly alternative for regular diesel as it has many advantages, and the most important thing is derived from environmental-friendly source, such as microalgae. Several microalgae are known for being able to synthesize lipids and even higher concentration. Newly microalgal strains …
During the internship, the main project done is the Water for injection hold time study at room temperature. Water for injection is a type of pure water used in pharmaceutical production that has been treated using distillation. Water for injection is used for cleaning equipment, mixing solutions, and validating cleaning. The study aims to investigate the condition of water for injection for…
With the rising popularity, herbal medicine has increasing consumption with a minimum 80% worldwide population or use it as their primary medicine depending on their culture and location. The usage of herbal medicine during pregnancy in Indonesia was reported to be 60% in 2020 due to an attempt to alleviate common side effects of pregnancy. However, herbal medicine has not been regulated en…
Social media has become a widespread tool for businesses, offering an affordable and accessible digital platform. Particularly for small businesses facing budget constraints, limited expertise, and competition from larger companies, social media provides an opportunity to overcome these challenges. On the other hand, the growth of the tourism industry in Bali has led to increased participa…
The continuing COVID-19 pandemic has brought to light how crucial it is to comprehend the SARS-CoV-2 virus and its proteins in order to develop efficient treatment and diagnostic approaches. However, there are difficulties with storage, processing, and analysis because of the enormous number of SARS-CoV-2 protein sequence data. In order to analyze SARS-CoV-2 data, this study examines the …
Social media has become a widespread tool for businesses, offering an affordable and accessible digital platform. Particularly for small businesses facing budget constraints, limited expertise, and competition from larger companies, social media provides an opportunity to overcome these challenges. On the other hand, the growth of the tourism industry in Bali has led to increased participa…
Red fruit oil (Pandanus conoideus Lam.) is a carotenoid rich oil originating from Papua and a potential source of natural food colorant. Due to its volatile form, a preservation method through encapsulation by spray drying was applied in this study. Maltodextrin and whey protein isolate were used as carrier agents, five formulations were made at different concentrations (formula A (MD only),…
Sweet soy sauce is a popular condiment in Indonesia, and it is mostly available in liquid form. Converting the product into powder form could provide several benefits, such as lower distribution cost and utilization in more types of product. In this study, sweet soy sauce was spray-dried in three different formulations (sweet soy sauce solids:maltodextrin ratio of 2:1, 1:1, and 1:2) and t…
Noodles are a staple food in Asia. However, since it is made using wheat flour which is high in carbohydrate, protein enrichment by adding other ingredients like cricket powder and nutritional yeast can be done. This study aimed to increase the protein content in noodles by incorporating cricket powder and nutritional yeast with different substitution levels (10, 15, and 20%) towards the …
This study aimed to develop a lipid-based paste form of Ready-to-Use Complementary Food (RUCF) using locally available ingredients, while investigating the physicochemical changes during 21 days of storage. Three formulations were proposed and assessed using B one touch viscometer for viscosity, CS410 handheld colorimeter for color, pawkit water activity analyzer for water activity, and e…
Dengue virus (DENV) is a major pathogen of concern globally. Infection with this mosquito-borne virus causes debilitating acute febrile disease that occur in over 128 countries putting more than 3.9 inhabitants to be at risk of the infection. If left untreated, the fatality rate for severe dengue can reach 20%. A vaccine that effectively prevents infection …
As one of the defense mechanisms of the body, inflammation has both beneficial and detrimental roles to the body. Inflammation Is a process involving the immune system to eliminate harmful substances that invade the body, thus beginning the healing process. Inflammation could also cause several detrimental effects, such as tissue injury and protein denaturation, which increases vascular permeab…
Skin inflammatory disease such as psoriasis and atopic dermatitis still remains a major problem because of their chronic nature. Treatments for atopic dermatitis and psoriasis has been solely focused on symptom management. Recently, it has been reported that phytochemical compounds from Calophyllum inophyllum seed possesses anti-inflammatory activities. However, little is known about its anti-i…
Cacao (Theobrama cacao L.) is rich in antioxidants of polyphenols and flavonoids. Because of its antioxidant, cacao has many health benefical effects including antidiabetic. During chocolate production, fermentation becomes the most important part for cacao beans. This is because cacao will not produce great flavors without the fermentation. there are many cacao not in good quality because the …
The utilization of naturally occurring bioactive compounds has been increasing in recent years. These compounds possess various pharmacological activities to improve the health state or act as prophylactic agents. Kombucha is a fermented beverage that employs the symbiotic relationship of bacteria and yeast (SCOBY) to produce secondary metabolites consisting of bioactive compounds, which offer …
Cancer is one of the leading causes of death in 2018. Two of the most common cancers are breast cancer and colorectal cancer with the incidence of 11.6% and 10.2%, respectively. The current treatments of cancers are limited to surgery, chemotherapy, radiotherapy, and targeted therapy. However, these treatments could induce cell resistance and some of them, notably chemotherapy and radiotherapy…
This study focused on evaluating the functional properties and proximate composition of uncooked (UC) and precooked (PC) durian seed starch (DSS). There is, however, a lack of research on the functional properties of treated durian seeds. The study involved sorting and processing durian seeds into UC and PC flour, followed by starch extraction using the alkali-steeping method. Multiple roun…
Phytophthora infestans is a devastating disease that caused the unfortunate 1845 – 1852 Irish Famine, leading to 25% decline of the population of Irish people and still impacts the whole crop ecosystem in temperate potato growing regions. Therefore, scientists have been researching on preventions that are capable of preventing outbreaks and the spread of this pathogen. This project would like…
Nutrition basics -- Preconception nutrition -- Preconception nutrition: conditions and interventions -- Nutrition during pregnancy -- Nutrition during pregnancy: conditions and interventions -- Nutrition during lactation -- Nutrition during lactation: conditions and interventions -- Infant nutrition -- Infant nutrition: conditions and interventions -- Toddler and preschooler nutrition -- Toddle…
This report summarizes a total of 2 months of internship project at the Faculty of Science, Mahidol University, Thailand. This internship project takes place in the science department more specifically in the organic chemistry laboratory. During this internship, the authors tried to synthesize and investigate the intermediates of kusunokinin to enhance its anticancer activity. Kusunokinin inter…
The current report describes the experience that the author gained during her 11 months of internship placement at Indonesia International Institute for Life Sciences (i3L). The internship was organized by Ms. Elizabeth Sidhartha, B.Sc., M.Sc. (a Biomedicine faculty) and was conducted online. The goal of this internship is to produce a systematic review discussing the potential of Plasmodium fa…
Fungi, particularly medicinal mushrooms, have been extensively harvested for their natural compounds for alternative medicine because they provide benefits with little to no adverse effects. FIPs, or fungal immunomodulatory proteins, are one that have been extensively studied for their immunomodulatory activities to promote lymphocyte production and subsequently enhance cytokine production. FIP…
The alteration of mechanical and frictional forces composed of pulsatile and shear stress in the aorta is postulated to play a significant role in the abdominal aortic Aneurysm (AAA) pathogenesis. Accordingly, cumulative evidence was gathered to investigate the mechanicalcues, which were believed to have a role in triggering a cascade of signaling events during the shear-induced AAA development…
Mahidol University is one of the best Campuses in Thailand, which focused on science and medicine. Organic chemistry is part of the department that mainly focuses on the synthesis of natural compounds as well as finding new synthetic methods that are more effective. In this internship oppurtunity, the author got a chance to experience how to work as a chemist. Specifically, this internship proj…
Milk-based drink is defined as a drink made using fresh milk, reconstituted milk, or recombined milk, which can be added with other food ingredients and sterilized or pasteurized. At PT. Garudafood, 40-50% of process water were incorporated into chocolate milk-based drink products, thus the quality of process water must be tightly regulated. This research was conducted to identify the impact of…
Soy sauce is a liquid condiment that is made from fermented soybeans with mold, wheat flour, brine water, bacteria, and yeast. Soy sauce fermentation includes two stages of fermentation which begins with koji fermentation and ends with moromi fermentation. Koji fermentation is a solid- state fermentation through the use of mold and it may last for 48 to 72 hours. Meanwhile, moromi fermentation …
Soy sauce is a popular condiment in Asian countries made from fermented soybeans. The production process of traditional soy sauce usually takes place in a non-sterile environment, causing spontaneous fermentation by indigenous microorganisms. One of the commonly found and reported species in soybean-based fermented food was Bacillus subtilis. Although Bacillus is generally recognized as saf…
The COVID−19 pandemic has been going on for three years, and research on preventive and curative measures is continuously being made. Belonging to the same coronavirus family, human common cold coronaviruses (CCCs) like 229E, NL63, HKU1, and OC43 have been around for decades. However, unlike SARS−CoV−2, they do not manifest serious signs and symptoms. Reports on T−cell cross−reactivit…
The skin provides conspicuous signs of aging, and many people are willing to spend a grand amount of money to keep their youthful appearance. Nowadays, treatments to delay the signs of aging in the skin are available, but most people favor the use of topically applied serum, due to its high concentration of active ingredients and comfortable finish product. This project highlights the evalu…
Staphylococcus aureus is a bacteria that has gained significant attention due to the emergence of antibiotic resistance. Some of the factors that contributed to the development of antibiotic resistance are associated with the formation of biofilm. Abelmoschus manihot and Tinospora crispa are recognised to have antimicrobial activity and its expected to have biofilm inhibitory effect. In this…
Sugar is one of the basic needs of the Indonesian population which tends to increase along with the increase in population. Sugar from starch generally has a taste and sweetness almost the same as granulated / table sugar (sucrose), some are even sweeter. Glucose and fructose are some of the sugars that are made from starch (cassava, potato, sago, and cornstarch). Among the sugars from star…
People all around the world are shifting towards eating more plant-based food, the vegan consumers and communities are rapidly increasing. However, there is a challenge in the development of plant-based meat analogue to mimic the characteristics of animal based products, especially for the juiciness and textural properties. Hydrocolloids can be used to improve the quality attributes of plant-ba…
Japanese curry is a popular and highly nutritious meal containing meat, vegetables, and abundant spices. Heat processing reduces the stability of meat towards oxygen, increasing the risks of food oxidation, leading to the destruction of the sensory properties and nutritional value of ready-to-eat meals. Rosemary (Rosmarinus officinalis) is a natural antioxidant that has been approved for use as…
Japanese curry is a popular dish which contains a high amount of spices, which provides the dish with quite a considerable amount of antioxidant activity. Even if curry may contain a high amount of spices, curry itself also contains a moderate amount of fat and oil which is involved in its production. Due to the moderate amount of fat and oil in curry, the product will be susceptible to auto-ox…
Avocado seed is more useful than just being a byproduct of avocado processing since it contains a lot of phenolic compounds. However, the phenolic compounds are rather prone to be damaged by environmental stress and by applying encapsulation techniques, they can be protected from the environmental stress. Thus, this study focuses on researching the effect of the presence of core and the core be…
Avocado seed (AS), a by-product of avocado, contains a high level of polyphenols which contributes to total antioxidant capacities (TAC) of avocado. However, polyphenols need to be encapsulated due to their sensitivity towards environmental stress. This study only observed the effect of the presence of core, the emulsification, coacervation, and freeze-drying steps of complex coacervation, and …
Plant-based nugget (PBN) is a succulent and firm alternative to the chicken nugget with a meat-like texture. PBN often has low sensory acceptability compared to chicken nugget and the direct fat incorporation was reported to cause fat leakage during cooking and the effect was suboptimal. Therefore, the effects of structured fats (solid and liquid mixture) incorporation in the form of emulsion t…