Bacterial cellulose (BC) is a promising packing material as it is biodegradable, non-toxic, has good mechanical properties, and can form bonds with foreign particles. Meanwhile, P. acidilactici postbiotics (metabolites) have the potential to be a natural food preservative as they contain antimicrobial compounds that are heat- and pH-stable. This research aims to develop a novel antimicrobia…
Hydroponic cultivation has emerged as a cost-effective alternative to traditional soil-based agriculture and may be less susceptible to pests and diseases. They can be set up in controlled environments, making them suitable for year-round production in urban areas with limited land availability. EM4 is a type of fertilizer that can increase agricultural systems' decomposition, composting, a…
Wound dressings play a crucial role in promoting efficient wound closure and healing by providing an environment conducive to tissue repair. Traditional wound dressings, such as cellulose-based gauze, often exhibit challenges in adhesion and exudate absorption, necessitating frequent replacements that may cause additional trauma. Biocellulose (BC), derived from bacteria, presents a natural c…
Bacterial cellulose (BC) is a biopolymer currently being coveted for its versatility, sustainable sourcing and biodegradability. The Indonesia International Institute for Life Sciences (i3L) lab has been conducting research on BC fermentation and surrounding BC produced by the kombucha isolate Komagataeibacter intermedius, with past findings showing a great prospect of the bacteria being abl…
The therapeutic benefits from the utilization of the roots and leaves saga plant have been known to Asian cultures for centuries. Numerous studies have attributed the therapeutics properties to triterpenoids, a class of secondary metabolites found in plants that are produced by the plant defense system under stressful environmental conditions. Recent study in legume model plant, lotus japon…
Black sapote is an underutilized fruit with various bioactive compounds and medicinal properties. To increase its utilization and value, the black sapote was turned into kombucha and spray-dried to increase the shelf life and stability of its active components. Encapsulating agents are used to protect the bioactive compounds during spray drying. This study investigated the effect of ferment…
The demand for fresh-cut fruits and vegetables (FFVs) has expanded due to consumer preferences for nutrition, safety, convenience, and ready-to-eat. However, FFVs are highly susceptible to surface browning and microbial spoilage. Active packaging (AP) offers a promising method to enhance shelf life and quality of FFVs. In this study, cellulose acetate-based active packaging films infused wi…
Dry eye disease (DED) is a common ocular disorder with multiple underlying causes. Carboxymethylcellulose sodium (CMC-Na) is frequently used in artificial tear formulations to alleviate DED symptoms. Different CMC-Na types from various brands can exhibit varying degrees of substitution (DS) and viscosity, leading to variations in filtration process performance and stability in formulations.…
Keratoconus presents a significant challenge in ophthalmology, urging effective treatment strategies to mitigate its impact on patients’ lives. This study investigates the safety and efficacy of combined therapy, utilizing rose bengal (RB) and riboflavin (RBF) for keratoconus management. Through ex vivo and in vitro experiments, significant increases in corneal stiffness and cell viability…
The skin is a vital outer layer that serves as protection. Once the protective layer is disrupted, for example the formation of wounds due to outer layer damage, it may increase the likelihood of contraction skin infection, which is a global burden. When open wounds are in contact with microorganisms, it allows attachment and proliferation, resulting in the development of biofilms. Antibiot…
Numerous health benefits of medicinal plants are attributed to the abundance of phytochemicals. Among these plants is Elaeocarpus grandiflorus, an endemic tree native to Southeast Asia. The locals utilize its leaves, fruit, endocarp, and bark to treat a variety of illnesses, such as acute intestinal inflammation, diarrhea, and urinary tract infections. This study aims to evaluate and quantif…
The healthcare industry has undergone a remarkable transformation in recent years due to technological advancements and digitalization. To address the need for accessible genomic healthcare information, GNOMED (Genomics Education) has been developed, a web application empowering patients with comprehensive reports from authorized genomic experts. Utilizing a rapid application development (R…
This subchronic toxicity study assessed the delayed toxicity and reversibility of fennel extract in male and female mice. To ascertain any delayed toxicity and potential for recovery, a separate satellite group received oral doses of fennel extract at a dose of 1000 mg/kg/day of body weight for a duration of 90 days, followed by 28-days with no treatment. There were no abnormalities observed in…
The gut microbiota represents a vast reservoir of bioactive substances with potential implications for human health and disease. This study focused on the identification of a novel metabolite originating from the gut microbiota strain Aneurinibacillus aneurinilyticus and evaluated its antibacterial properties. Advanced analytical techniques such as high-performance liquid chromatography, high-r…
Shampoo is a type of hair care product that is used to clean the scalp and remove the dirt. Not only for humans, shampoo is also used for animals, especially dogs. However, different from human shampoo, dog shampoo tends to be milder due to the different pH and sensitivity of dog’s skin compared to human skin. It is important to formulate a shampoo that has good properties for dog characteris…
Foeniculum vulgare or known as adas in Indonesia is a medicinal plant that belongs to the umbelliferae family. It has a lot of pharmacological properties such as antiviral, antimicrobial, antioxidant, anti-inflammatory, anti-anxiety, gastro-protective, estrogenic-like, cardiovascular, lipid-lowering, anti-mutagenic, anti-diabetic, anti-cancer activity, hepatoprotective, and memory-protective ch…
F. vulgare is a perennial herb that has been traditionally used as medicine for a variety of ailments. It has also been used as a medication due to its antimicrobial, antifungal, and antiviral properties. Previous studies have highlighted issues associated with the poor quality of therapeutic herbal products commercially available, thus a standardization for safety and toxicity profiling of her…
The crisis of antibacterial resistance is an inevitable consequence of the widespread use of antibacterial agents in human health-related settings and agriculture. One of the oldest strategies to combat this crisis is to screen for novel antibacterial drug classes or structures, leading to the discovery of numerous antibacterial compounds, many of which are isolated from actinomyces/ Streptomyc…
In recent years, the food industry develops functional food which produces health benefits to the customer and the beverage industry is a suitable sector to explore. Therefore, this project aims to develop a collagen drink using the Thong Pha Phum GI (Geographical Index) rambutan as a locally grown fruit in Thailand. The main objective is to observe the effects of different concentrations of ra…
Cardiovascular diseases (CVDs) are mainly caused by postprandial lipemia (PPL), an increase of triglycerides-rich lipoprotein level in blood between time after a meal. Food consumption containing dietary fiber has been reported to lower blood triglycerides accumulation. Hence, this study aims to understand the effect of soluble non-viscous dietary fiber towards the lipid absorption in the food …
The consumption of low or zero−calorie carbonated soft drinks (CSD) which utilize artificial sweeteners are growing in popularity as it can provide sweetness without adding calories. A blend of acesulfame−K and sucralose is known to exhibit good taste results in comparison to sugar−containing products. In this study, different concentrations of sweetening agents (100% sucrose, 60% sucrose…
The prevailing ubiquity of carbonated beverages in the consumer market is coupled with concerns regarding their high sugar content, which is implicated in health risks such as obesity, cardiovascular diseases, type II diabetes mellitus, and certain cancers. Acknowledging these health implications, PT Sinar Sosro is actively reformulating its products to reduce sugar content. This project focuse…
Wolffia spp. had garnered attention as a potential "superfood" due to its reported nutritional value, offering a promising solution to the escalating global obesity crisis. Nonetheless, Wolffia spp. exhibits a moisture content of approximately 95% post-harvest, necessitating a drying procedure to reduce the microbial growth and facilitate storage, packaging, and transportation. This study focus…
Enzymatic hydrolysis can overcome the problem about the quality of the instant porridge. The process was divided into 3 steps, gelatinization, liquefaction, and saccharification. The glycosidic chain will be broken down by the amylase and turn the starch into a maltose and glucose that gives natural sweetness and better mouthfeel. Hydrolysis really depends on the temperature as the enzyme might…
Tea consumption in Indonesia is on the rise including Ready to Drink (RTD) tea. TehBotol Sosro is the one of the popular ready-to-drink (RTD) tea brand in Indonesia. Tehbotol Sosro is famously known for not having preservatives in its beverages. It only consists of water, tea, and sweetened with sugar and contains no artificial ingredients. The physicochemical properties, such as pH, brix level…
Increasing demand as well as interest for plant−based ingredients such as konjac was occurring. Additionally, in order to stabilize the prices, extend shelf life, and enhance added value of peaches, various processing methods and products must be developed. White peach has a good insight from the market due to its premium imported fruits that can't be cultivated in Indonesia. However, in this…
Sarcopenia, an age-related disease where loss of muscle and strength progresses, has become a research interest for scientists over the past few decades. Sarcopenia in and of itself can cause physical incapacity, functional impairment, and even death to patients. Research has shown that mitochondrial dysfunction has been known to cause sarcopenic muscle tissue damage. Furthermore, recent studie…
Infantile spasm is a type of epilepsy that occurs in infants that is characterized by the sudden movement throughout the whole body. It is crucial to detect the disease and undergo suitable treatments as soon as possible in order to minimize the potential negative long-term effect in learning development. One of the most effective treatments is the usage of anti-epileptic drug Vigabatrin that i…
Noodles are a staple food in Asia. However, since it is made using wheat flour which is high in carbohydrate, protein enrichment by adding other ingredients like cricket powder and nutritional yeast can be done. This study aimed to increase the protein content in noodles by incorporating cricket powder and nutritional yeast with different substitution levels (10, 15, and 20%) towards the …
This study aimed to develop a lipid-based paste form of Ready-to-Use Complementary Food (RUCF) using locally available ingredients, while investigating the physicochemical changes during 21 days of storage. Three formulations were proposed and assessed using B one touch viscometer for viscosity, CS410 handheld colorimeter for color, pawkit water activity analyzer for water activity, and e…
Milk-based drink is defined as a drink made using fresh milk, reconstituted milk, or recombined milk, which can be added with other food ingredients and sterilized or pasteurized. At PT. Garudafood, 40-50% of process water were incorporated into chocolate milk-based drink products, thus the quality of process water must be tightly regulated. This research was conducted to identify the impact of…
Soy sauce is a liquid condiment that is made from fermented soybeans with mold, wheat flour, brine water, bacteria, and yeast. Soy sauce fermentation includes two stages of fermentation which begins with koji fermentation and ends with moromi fermentation. Koji fermentation is a solid- state fermentation through the use of mold and it may last for 48 to 72 hours. Meanwhile, moromi fermentation …
Soy sauce is a popular condiment in Asian countries made from fermented soybeans. The production process of traditional soy sauce usually takes place in a non-sterile environment, causing spontaneous fermentation by indigenous microorganisms. One of the commonly found and reported species in soybean-based fermented food was Bacillus subtilis. Although Bacillus is generally recognized as saf…
Japanese curry is a popular dish which contains a high amount of spices, which provides the dish with quite a considerable amount of antioxidant activity. Even if curry may contain a high amount of spices, curry itself also contains a moderate amount of fat and oil which is involved in its production. Due to the moderate amount of fat and oil in curry, the product will be susceptible to auto-ox…
Plant-based nugget (PBN) is a succulent and firm alternative to the chicken nugget with a meat-like texture. PBN often has low sensory acceptability compared to chicken nugget and the direct fat incorporation was reported to cause fat leakage during cooking and the effect was suboptimal. Therefore, the effects of structured fats (solid and liquid mixture) incorporation in the form of emulsion t…
This study observed the physicochemical and microbiological stability of plant based meatballs made from local ingredients which are vacuum packed and frozen. During frozen storage, deterioration happened gradually caused by microbial growth and physicochemical changes. Thus, the microbial content including bacteria (TPC), yeast and mold (TYMC), and physicochemical aspects including water a…
Breast cancer is the most common cancer in woman and the second leading cause of cancer deaths in the world among women. Research have shown the efiicacy of phytochecmicals as asupplementary treatment in breast cancer through the regulation of gene and microRNA (miRNA) expression. This study aims to identify differentially expressed miRNA-gene pairs in breast cancer across different stages in o…
Pediococcus acidilactici has gained a lot of interest lately due to its ability as a potential probiotic strain. However, concerns regarding its viability and stability during consumption and storage lead to a solution to utilize spray dry as an encapsulation method for Pediococcus acidilactici. Yet, the utilization of spray drying could affect the cell viability and its functional probiotic pr…
Preimplantation genetic testing (PGT) is a process to prioritise in vitro fertilised embryos without genetic defects for implantation. One of the conditions screened is aneuploidy. The genetic testing for chromosomal aneuploidy ensures that all 23 pairs of chromosomes have the correct copy number. The research utilized amplicon sequencing to generate sequence data and variant calling to p…
PT Kalbe Milko Indonesia combines pasteurization and retort sterilization on producing their sterilized milk product. The pasteurization process takes place at 85 ± 3°C for 30 seconds and after packing, the product is sterilized in retort machines at a temperature between 121 and 121.9 °C. Nevertheless, milk's quality is not just influenced by production processes but is also affected by oth…
Rice (Oryza sativa) is a vital food, accounting for one-fifth of all calories humans consume globally. Because of its numerous health-promoting properties, colored rice has become a functional food ingredient. Rice can be consumed in various ways; however, research into rice milk and its applications is still limited. Re.juve constantly expands its product line to more delicious and healthy foo…
Southeast Asian Ovalocytosis (SAO) is a hereditary genetic disorder caused by a 27 bp deletion in the SLC4A1 gene, leading to a disrupted folding at the extracellular face of the SLC4A1 protein in the red blood cell (RBC) membrane. SAO is an autosomal dominant disorder where heterozygous individuals are asymptomatic and homozygous SAO are considered embryonic lethal. SAO can be observed microsc…