Exploring the Impact of Andaliman (Zanthoxylum acanthopodium) Fruit Crude Ext…

This study investigates the anti-inflammatory properties of Andaliman (Zanthoxylum acanthopodium DC.) fruit extract on inflamed human keratinocytes (HaCaT cells). The phytochemical profile of Andaliman reveals a high content of terpenoids from the Salkowski test, which inhibits the NF-κB signaling pathway, thereby suppressing pro-inflammatory cytokine production. The study demonstrates a s…

The Therapeutic Potential of DX23 in Elevating Neutrophil Antimicrobial Defense

Neutrophils play an important role in the innate immune mechanism. During pathogen encounter, these cells gather at the infection site and perform various functions. Neutrophil could effectively eliminate pathogens by performing their functions such as respiratory burst, degranulation, phagocytosis, and formation of neutrophil extracellular traps (NETs). Therefore, neutrophil activation eme…

Evaluating the Role of Gene X in Pancreatic Adenocarcinoma (PAAD) Survivabili…

Pancreatic adenocarcinoma (PAAD) remains a life-threatening disease with the most unfavorable prognosis among all cancer types. This is mainly due to the high rate of cell survivability marked by rapid cell proliferation and migration activity. Despite having KRAS oncogene as a known commonly mutated driver gene, targeting it has been challenging and has hindered the development of effective…

Investigation of the Antifungal and Anti-inflammatory Properties of Alpinian …

Candida albicans is a yeast that resides on the human skin, however it can become an opportunistic pathogen when the immune system is compromised or there are imbalances in the microenvironment. This microorganism can cause candidiasis which is able to cause high mortality rates in especially immunocompromised patients. Treating this infection is highly difficult due to similarities in stru…

"Construction of Mini-genome System for both Rabies virus Laboratory Strain a…

Rabies virus (RABV) causes a zoonotic disease known as rabies that affects humans and mammals. With a genome length of 12 kb, RABV is classified as a non-segmented, negative-stranded RNA virus that encodes five different structural proteins. The nucleoprotein (N), phosphoprotein (P), and large RNA polymerase protein (L) forms ribonucleoprotein (RNP); together with the viral genome it serves …

Investigating the Role of HDXX as a Novel DNA Damage Response Protein in Colo…

Colorectal cancer (CRC) ranks third in cancer incidence and cancer-related mortalities worldwide. The transformation of normal colon and rectal cells to malignant adenocarcinomas due to unrepaired DNA damage which leads to oncogenic mutations. These mutations also increase the frequency of DNA damage, leading to endogenous replication stress (RS). This introduces an opportunity to induce sy…

The Utilization of Next Generation Sequencing in Analyzing HIV Whole Genome

Human Immunodeficiency Virus (HIV) is a retrovirus responsible for causing acquired immunodeficiency syndrome (AIDS). The pol gene of the HIV genome encodes protease and reverse transcriptase, and integrase region which is responsible for viral infection and survival inside the host cell. Antiretroviral Therapy is usually administered to target these regions due to their significance in vir…

Immunoinformatics Study of Potential Molecular Mimicry between Viral T-Cell E…

There have been reports regarding the autoimmunity induced by SARS-CoV-2 in COVID-19 patients, such as: GBS, SLE, multiple sclerosis, demyelinating neuropathies, and orthostatic tachycardia syndrome, narcolepsy, even vaccine-induced. However, the exact mechanism is still unclear. One of possible reason is molecular mimicry, a condition in which the T-cell epitopes come from the virus antige…

IFM is a Potential Key Player in AML Cell Survival and CML Cell Resistance to…

Myeloid leukemia is characterized by the excessive proliferation of myeloid cells within the bone marrow. It is categorized into acute (AML) and chronic (CML) myeloid leukemia, with distinct etiologies and therapeutic complexities. The genetic heterogeneity of AML contributes to varying treatment responses, leading to a high mortality rate. One gene that has been identified as an adverse pro…

In vitro Investigation on The Anti-adherence and Antibacterial Effect of Lact…

Humans have been co-existing with a whole population of microbes, where trillions of different microbes are living inside the human GI tracts as a commensal gut microbiota. This condition provides a mutual relationship where the gut microbiota serves as a natural protection for the intestinal tract homeostasis. Nevertheless, the human intestinal tract is constantly exposed to environmental …

In Silico Design and ELONA Validation of an Aptamer for SARS- CoV-2 Omicron R…

COVID-19, caused by the SARS-CoV-2 virus, has resulted in a pandemic with 6.8 million confirmed cases in Indonesia as of December 2023. The high number of cases has necessitated the need for robust and specific diagnostic tools. Despite its effectiveness, the qRT-PCR suggested by the World Health Organization has a number of drawbacks, such as expensive costs, the need for trained personnel …

Investigation on Effect of Cell Seeding Number Toward Hepatic Multicellular T…

Cancer remains a global health challenge in need of precise, cost-effective, and scalable research tools for comprehensive investigations. Spheroid-based methodologies emerge as reliable, easily adaptable, and highly scalable techniques, offering an improved representation of in-vivo conditions compared to conventional 2D cell cultures. This study utilizes the Huh-7 cell line to generate hep…

Electrophysiological Evaluation of the Left-Right Asymmetry of MHb-IPN Pathwa…

The Medial Habenula-Interpeduncular Nucleus (MHb-IPN) pathway is an emerging with recently discovered roles in fear memory expression. As ongoing research revealed the asymmetric functions of this pathway in mammals, questions were asked regarding the developmental origins of this asymmetry, particularly its relation to the visceral asymmetry. This study set out to investigate the lateral a…

Red Fruit Oil Co-Crystal Development as a Natural Food Colorant by Utilizing …

Red fruit oil (RFO) extract serves as a natural red colorant but exhibits limitations related to solubility and susceptibility to environmental factors such as oxygen, heat, and light-induced degradation. Encapsulation through co-crystallization represents a promising approach to mitigate these challenges. In this context, erythritol is employed instead of sucrose during co-crystallization t…

The Product Development of Alcohol-Free Craft Beer from Thai Bitter Melons (M…

This research aims to develop an alcohol free craft beer utilizing Momordica charantia, otherwise known as bitter melon, as a hops substitute. This study substitutes hops with 0%, 25%, 50%, 75%, and 100% of bitter melon. The alcohol free beer was prepared by malting, mashing, brewing, fermentation, and incubation, followed by giving heat treatment to the beer separating them into non-heat t…

The Effect of Alpha-Amylase Types and Time of Enzyme Activation Towards the S…

Plant-based or non-dairy milk substitutes are becoming favored in the growing field of functional beverages driven by factors such as health benefits, allergies, lactose intolerance, and the rise in vegan diets. However, there are challenges to producing oat milk, such as achieving the desirable texture and taste. This study is aimed to have 4 treatments utilizing 2 different kinds of amylas…

Comparing Physicochemical Properties Of White Bread Produced Using Natural Ye…

The choice of yeast, whether it's grape yeast or commercial yeast, depends on the baker's objectives and preferences. Grape yeast is ideal for experimental bakers seeking unique flavors, while commercial yeast offers reliability and consistency. In a recent study, the physicochemical properties (water activity, texture, and moisture content) of white bread made from grape yeast and commercia…

Physicochemical and Sensory Properties of Steamed Banana Cake Made From Banan…

Bananas are one of the most popular fruits consumed in Indonesia. It is the fruit that Indonesia produces the most, with 9.2 million tons produced in 2022 and 91 kg consumed weekly per person. Vitamins and minerals are all found in good amounts in bananas. Bananas are a versatile fruit that can be used for various kinds of food, such as banana cake. However, banana cake contains gluten and …

Extraction Optimization of Gotu Kola (Centella asiatica) Leaf using Ultrasoun…

The food technology industry is increasingly interested in innovative ways to include nutritious ingredients that promote health in food products. The leafy green plant that we used as a traditional medicine known as Gotu Kola (Centella asiatica), which is regional to tropical and subtropical regions of Asia, has drawn a lot of interest from the food technology sector due to its potential to…

The Effect of the Utilization of Lavender (Lavandula angustifolia) and Butter…

Currently, snacking has become a daily staple food as Indonesians consume more snacks compared to proper meals. Cereal bars have been well-known as a convenient snack that is easy to prepare and can be consumed anywhere. Given the current trend for cereal bars, ingredients that could produce a palatable cereal bar with sufficient nutritional content must be taken into account so the needs of…

The Effects of Baking Parameters on Sensory Properties of White bread Made wi…

White and sweet bread consumption in Indonesia grew to 3.01 kg/capita/year in 2020. This surge is due to bread's ease of preparation and consumption. Bread is a food product composed of wheat flour, water, sugar, salt, butter, and yeast. Yeast that is used to make bread is frequently dry yeast or instant yeast. Saccharomyces cerevisiae is the primary yeast in bread making. Natural yeast, de…

Effects of High-Pressure Processing on the Physicochemical, Microstructural, …

Negative effects on meat consumption have prompted the rise of protein alternatives. Although chicken is rich in protein, it has no dietary fibre. Hence, alternative fibre and protein-rich ingredients can be found in shiitake mushrooms with an umami flavour and tempeh with a dense texture. High-pressure processing (HPP) can improve the texture and technological functionalities of various foo…

Comparative Analysis of High-Pressure Processing Effects on Physicochemical, …

Excessive meat consumption's negative effects have driven the development of meat alternatives. While chicken is protein-rich, it lacks fiber, so mushrooms were used for their high fiber content, and jackfruit's fibrous texture to mimic chicken. High-pressure processing (HPP) improved texture and preserved nutritional value. This study aimed to develop nuggets using chicken, hybrid, and PBM…

The Effect Of Baking Parameters On Physicochemical properties Of White Bread …

Bread is widely favoured food due to simple composition and convenient suitability for daily consumption. One of the main ingredients used to determine the bread quality is yeast. As the Indonesian bread industry has grown, bread is being processed by replacing instant yeast with natural yeast because of increasing consumer interest natural products. Natural yeast is obtained from fermented…

Utilization of Snake Fruit (Salacca Zalacca) for Arak Using Distillers Active…

Arak, a traditional Indonesian spirit typically produced from rice or sugarcane, is made by fermenting rice or fruit juice followed by distillation. This research explores using snake fruit (Salacca Zalacca var Pondoh) as an innovative raw material for Arak production, offering a novel flavor profile and creating a niche market. Snake fruit, containing fermentable sugars, presents a cost-eff…

The effects of IFNγ, TNFα, and Dexamethasone onthe Immunopeptidome of Diffu…

Diffuse Intrinsic Pontine Glioma (DIPG) is a malignant tumor found in the brain stem which mainly affects children. It has an aggressive nature with no available curative treatment. Cancer immunotherapy using specific tumor antigens to target tumor cells may be a viable alternative therapeutic option for DIPG, however antigen presentation is highly downregulated in tumors. This study aims t…

Investigation of Gene Dependencies in Paediatric Tumour Models Using CRISPR-C…

Paediatric cancer accounts for the majority of cancer-related mortality in children. Although current treatment increased the overall survival rates, young individuals often encounter life-long side effects from toxic therapies. Therefore, there is an urgent need for targeted therapies aimed at tumour-specific vulnerabilities for greater specificity and reduced toxicity, in which precision m…

Optimizing Mycoprotein Production using Aspergillus oryzae in Soy Whey Substr…

Mycoproteins, that are produced through filamentous fungi fermentation, have gained popularity because of their rich protein content and sustainability as an animal-based protein alternative. However, the cost of the commerciallized mycoprotein exceeds the cost of regular meat. Therefore, scientists are exploring various inexpensive substrates and GRAS fungal strains with high survivability …

Investigating the Role of Tumor-Associated Neutrophils (TANs) in the Suppress…

Glioblastoma (GBM) is known as a highly aggressive and malignant form of brain cancer. Despite advances in understanding the genetic and molecular basis of glioblastoma, it has a poor prognosis with a median survival rate of 9 months. The complex interplay between malignant cells and the surrounding tumor microenvironment (TME) plays a pivotal role in tumor progression and treatment respons…

Plant Growth Promoting Bacteria (pgpb) Community Characterizations In Takakur…

This study focuses on the characterization of bacterial communities in Takakura compost specifically applied to Saga plants. Takakura compost, known for its simplicity, cost-effectiveness, and efficacy in producing high-quality compost, utilizes the natural processes of microorganisms to break down organic materials. The research involves the analysis of bacterial communities during the comp…

Investigating the Effects of Sodium Azide and Red Light Illumination in Two-S…

Indonesia is striving for a greener and cleaner future, and is pushing for the commercial application of biofuels. Currently Indonesia is focused on palm-oil based biofuels, but it comes with many negative impacts and challenges. Hence, it is necessary to improve upon biofuel production technology. Shifting towards third generation microalgal biofuels is an attractive option, as microalgae h…

Development Of Bacterial Cellulose Loaded with Pediococcus acidilactici Postb…

Bacterial cellulose (BC) is a promising packing material as it is biodegradable, non-toxic, has good mechanical properties, and can form bonds with foreign particles. Meanwhile, P. acidilactici postbiotics (metabolites) have the potential to be a natural food preservative as they contain antimicrobial compounds that are heat- and pH-stable. This research aims to develop a novel antimicrobia…

Characterization of Culturable Promoting Yeast and Fungi from Takakura Compost

Compost has an important ecological role in increasing soil fertility, plant growth and sustainable agriculture, especially in recycling organic waste. This research characterizes the role of Plant Growth Promoting Fungi (PGPF) derived from Takakura compost and analyzes the influence of microbial communities on saga plants (Abrus precatorius). Takakura Compost is an alternative because of i…

Cellular Exploration of Potential Synthetic Compounds for Advancing Drug Deve…

Psoriasis is a prevalent chronic autoimmune inflammatory skin disease affecting over 125 million individuals globally, posing a significant health challenge. Investigating synthetic compounds featuring the 1,2,3-triazole structure known for their anti-inflammatory effects, this research aimed to evaluate synthetic drug compound candidates for their anti-inflammatory properties. The assessmen…

Microbial Analysis and the Impact of EM4 Fertilizer Compared to AB Mix Indust…

Hydroponic cultivation has emerged as a cost-effective alternative to traditional soil-based agriculture and may be less susceptible to pests and diseases. They can be set up in controlled environments, making them suitable for year-round production in urban areas with limited land availability. EM4 is a type of fertilizer that can increase agricultural systems' decomposition, composting, a…

Investigating the Underlying Molecular Regulation Behind Methyl Jasmonate’s…

Abrus precatorius, colloquially known as the Saga plant, produces various secondary metabolites with valuable pharmaceutical properties such as glycyrrhizin and abrusoside. Methyl jasmonate (MeJA) is a phytohormone known to regulate the expression of the MYC2 transcription factor, which in turn promotes the biosynthesis of secondary metabolites in plants. Understanding the resolution to enh…

Characterization of Potential Plastic Degrading Bacterial Isolates for Lipase…

Overproduction of plastics and difficulty to degrade the plastic have become one of the major threats in the environmental sector. This plastic has been reported to accumulate in many different places. Many methods have been used to solve the problem but resulting in other harmful effects toward the environment. Methods by utilizing the enzyme from microbes can be feasible to perform withou…

Investigating The Effect Of Compost Supplementation On Abrus Precatorius To P…

Abrus precatorius, known as Saga, is a legume plant belonging to the tropical Asia region that is known for its toxicity. Precedent research has shown that Abrus precatorius leaves and roots have a potential effect on treating various diseases such as cough, bronchitis, hepatitis, and cancer. However, Saga plants are being undervalued in Indonesia due to the lack of knowledge on the benefit…

Development of Pediococcus acidilactici postbiotic loaded Biocellulose for Wo…

Wound dressings play a crucial role in promoting efficient wound closure and healing by providing an environment conducive to tissue repair. Traditional wound dressings, such as cellulose-based gauze, often exhibit challenges in adhesion and exudate absorption, necessitating frequent replacements that may cause additional trauma. Biocellulose (BC), derived from bacteria, presents a natural c…

Assessment of Calcium Carbonate as Minerals for The Growth Of The Marine Cope…

Aquaculture industries are evolving rapidly to meet the escalating global demand for seafood as the human population grows. Enhancing the nutritional quality of feed for aquatic animals, such as fish larvae, is critical for increasing seafood production sustainably. Live feed, particularly copepods (crustacean zooplankton), has emerged as a preferred alternative to conventional synthetic fee…

Semi-Quantitative Analysis of Triterpenoid Saponin in Hydroponics Abrus Prcat…

Abrus precatorius is a plant highly valued for its foods and medicinal benefits, notably due to the triterpenoid saponins that it can synthesize. The triterpenoid saponins produced are glycyrrhizin in the roots and abrusoside in the leaves. However, the yield of triterpenoid saponins in A. precatorius is low. To increase the yield, it can be induced by activating the stress condition for the…

Sacha Inchi (Plukenetia volubilis) Waste Utilization as a Substrate for Black…

Sacha Inchi is a plant which is best known for its medicinal properties and a food source. However the husk and the shell usually ended up as waste. As a result, this research aims to valorize the Sacha Inchi Waste as feed to grow Black Soldier Fly Larvae. In this experiment, 100 Black Soldier Fly Larvae were hatched in a container and after 5 days, feed made of press cake waste of Sacha In…

Competency Assessment of an Understudied Pediococcus acidilactici (0110

Pediococcus acidilactici is a gram-positive lactic acid bacteria (LAB) widely used as a probiotic due to its safety, benefits, and ability to survive in the harsh environment of the gastrointestinal (GI) tract. One of the challenges for probiotic species is the presence of bile salt, which can degrade bacterial cell membrane due to its main function in lipid solubilization. Bile salt can als…

Investigation of Ethyl-methanesulfonate (EMS) Treatment as A Mutagenesis Appr…

As the human population grows, the demand for organoleptic properties in food has linearly increased, including the use of harmful synthetic colorant. Therefore, carotenoids, as a secondary metabolites and natural compounds, can be used as an alternative to natural food preservatives. They are also attributed to antioxidant properties which are beneficial for human consumption and health. T…

Analyzing the Combined Anti-adipogenic Effects of Ginger and Turmeric on 3T3-…

Obesity, characterized by excessive adipose tissue, is linked to adverse health effects. Ginger, containing compounds like gingerol, shogaols, and zingerone, exhibits anti-cancer, anti-inflammatory, anti-diabetic, anti-hepatic steatosis, and antioxidant properties. Turmeric has potential as an anti-adipogenic agent by suppressing key regulators of adipogenesis. This study analyzed the anti-adi…

The authorized biography Sri Mulyani : no limits reformasi dengan hati

Edition

-

ISBN/ISSN

9786231606587

Collation

xiii, 577 p. ; 23 cm.

Series Title

-

Call Number

920 Dhan

Kebijakan bank sentral : teori dan praktik

Edition

-

ISBN/ISSN

9786024250287

Collation

xviii, 776 p. : ill. ; 23 cm.

Series Title

-

Call Number

332.11 Per k

Characterization of Komagataeibacter intermedius postbiotics collected from b…

Bacterial cellulose (BC) is a biopolymer currently being coveted for its versatility, sustainable sourcing and biodegradability. The Indonesia International Institute for Life Sciences (i3L) lab has been conducting research on BC fermentation and surrounding BC produced by the kombucha isolate Komagataeibacter intermedius, with past findings showing a great prospect of the bacteria being abl…

Optimization Of Erythritol Production Using Molasses as A Potential Carbon So…

Erythritol is a beneficial sugar alcohol that can be used as a sugar substitute for diabetic patients. It has 0.2 kcal/g calories and still has 70-80% sweetness with the widely used sucrose. Erythritol production through extraction and chemical synthesis is ineffective due to the small product yield, making the commercial production expensive, so alternative synthesis using biotechnology is …

Spatial Distribution of Triterpenoid in Root and Leaves of Saga Plants (Abrus…

The therapeutic benefits from the utilization of the roots and leaves saga plant have been known to Asian cultures for centuries. Numerous studies have attributed the therapeutics properties to triterpenoids, a class of secondary metabolites found in plants that are produced by the plant defense system under stressful environmental conditions. Recent study in legume model plant, lotus japon…