Estrogen receptor-positive (ER+) breast cancer accounts for 67-80% of all breast cancer subtypes. Endocrine therapies are initially given as part of first-line treatment, however 20% of the patients develop resistance. The overactivation of cyclin dependent kinase 4/6 (CDK4/6) is one of the underlying mechanisms. Hence the addition of CDK4/6 inhibitors such as palbociclib in combination with en…
The global food waste and wastewater treatment issue needs to be addressed because both can cause environmental, health, and economic issues. Food waste, in particular, is dominated by vegetable waste, both from the production and consumption phase. It has been found that some bacteria that grow on fermented vegetable waste can help decrease ammonium, phosphate, and neutralize pH in wastewa…
"The study delves into the characterization of bacterial communities within Takakura composting. Takakura composting is a method integral to organic waste management, and serves as the focal point for understanding microbial dynamics during decomposition. The research aims to make takakura compost with two different compositions and characterize the bacterial community in the Takakura compo…
Phosphorous acid is a safer and more environmentally friendly alternative to commercial pesticides as it contains a component called phosphite that exhibits fungicidal and bactericidal activities. Foliar spraying and soil drenching are two methods of exposure to phosphite that must be carefully conducted because an excessive amount of phosphite is toxic to plants, impairing their growth and dev…
Glioblastoma is the most prevalent type of malignant brain tumor, with a fatality rate close to 100%. The failure of glioblastoma treatment is mainly attributed to the high proliferation and invasion rate of glioblastoma cells, in addition to the presence of glioblastoma stem cells, all of which are regulated by the Notch signaling pathway. Past studies have observed that the Notch signaling…
The author was doing an internship at PT. Alamii Natura Sejahtera as a research and development intern for 6 months starting from July 2023 – January 2024. The author has several responsibilities including doing research for both optimizing existing product production processes as well as new product development. Additionally, the author also helps the team with the document-making for BPOM-r…
The increase in global seafood demand significantly affects marine ecosystems and results in limited seafood commodities or even reduced quality as the global human population increases. Aquaculture development has the potential to meet global demand by obtaining seafood commodities in a more sustainable approach. The firm focused on raising post-larvae Litopenaeus vannamei to a fully matur…
Tuak is an alcoholic beverage from Southeast Asian countries, such as Indonesia and Malaysia, prepared by fermenting starchy materials (e.g., rice, palm sap, coconut sap or water). Tuak production factors and recipes vary from one maker to another, including the type of substrate used, sugar level, water level, fermentation time, and even the starter culture used. These factors affect the micro…
his study dives into the vital importance of identifying Enterobacter in food as a preventive step for safeguarding global food safety and public health. Enterobacter species, both pathogenic and non-pathogenic strains, represent a hazard to food items, underlining the importance of robust safety standards. Historical outbreaks, such as the Peanut Corporation of America Salmonella event, hi…
Inflammation plays an important role in the body as a defense mechanism against pathogens, toxins, and dead cells. However, when the infection continues and inflammation becomes unregulated, acute inflammation eventually progresses into a chronic one, which holds responsibility for numerous chronic non-communicable diseases such as cancer, hypertension, diabetes, etc. various foods have bee…
This research project addresses the challenge of food waste at Hangry Indonesia, a cloud kitchen restaurant. Focusing on rice, a staple in their menu, the study aims to create a sustainable system to reduce food waste when sales fall short of targets. Additionally, the project explores the impact of reheating frozen rice on texture, specifically addressing issues such as browning and hard…
This study highlights the environmental consequences of landfill buildup while addressing the issue of insufficient food waste management in Indonesia and the 1.3 billion yearly instances worldwide. The study focuses on the Takakura Composting Method (TCM), which combines fermentative microorganisms and locally created materials to provide a sustainable household-scale solution. The Takakur…
This study aims to generate molecular infectious clones, incorporating reporter genes (GFP and SfCherry), for flaviviruses and noroviruses—namely, Kunjin, Zika, and Murine Norovirus (MNV). The objective is to use viral constructs for antiviral compound screening and unravel their mechanisms of action. Employing a diverse array of methods, including PCR, CPER, transfection, fluorescence, an…
Globally, colorectal cancer remains the third most common cancer to be diagnosed. Nonetheless, there are current therapies for colorectal cancer, including radiotherapy, chemotherapy, and surgery. Unfortunately, overuse of chemotherapy can lead to chemoresistance to specific chemotherapeutic agents. For instance, late-stage colorectal cancer is treated with oxaliplatin. On the other hand, o…
Wheat is one of the food sources in Indonesia that has one the highest consumption rates. With the rise in the consumption rate of wheat in Indonesia over the past year, the Indonesia’s government has to increase its import activity on wheat to maintain its supply. This can also cause most of Indonesian society to have high dependency towards the consumption of wheat. However, currently t…
This research aims to analyze the impact of EBV (Epstein-Barr virus) infection on cell cycle phases (G1, S, G2/M) during latent and lytic phases, exploring alterations in cell cycle regulatory proteins. The investigation extends to compare fixation methods' ethanol and paraformaldehyde. The focus lies in comprehending EBV's effect on host cell cycle progression, emphasizing viral reactivatio…
Glioblastoma is the most prevalent type of malignant brain tumor, with a fatality rate close to 100%. The failure of glioblastoma treatment is mainly attributed to the high proliferation and invasion rate of glioblastoma cells, in addition to the presence of glioblastoma stem cells, all of which are regulated by the Notch signaling pathway. Past studies have observed that the Notch signaling…
The overarching goal of this project is to comprehend the intricate dynamics of RNA viruses, specifically influenza A viruses, enteroviruses, and coronaviruses, which pose significant health threats. The focus lies in exploring hostvirus interactions, particularly the roles of host components in various stages of viral RNA replication, aiming to identify potential targets for antiviral interv…
"The human axilla hosts clusters of sweat glands that provide a favorable environment for a large bacterial population. The bacteria-driven process could convert the odorless secretions from the glands into volatile odorous compounds, leading to an unpleasant body odor that may disrupt people’s daily routines. To address this issue, the development of cosmetics like deodorant has the pote…
Jamu is an Indonesian traditional medicine drink made from rhizomes. However, it leaves pomace waste that possesses several environmental problems. Several efforts to reduce the waste accumulation could be performed, including using the pomace as a Pickering emulsion stabilizer. In order to obtain this function, the pomace needs to be dried first using an optimal temperature. Thus, this study a…
The small microRNA159 (miR159) strongly silences the expression of genes encoding GAMYB transcription factors. This gene is a regulatory gene that controls the transcription of multiple other genes. When miR159 is inhibited, the expression of GAMYB is activated, inhibiting plant growth, but also activating plant pathogen defens mechanisms, including the expression of CP1. The CP1 gene is used a…
Psoriasis is an autoimmune skin disorder that has impacted the global population from children to adults. Psoriasis is characterized by unusual proliferation of keratinocytes, leading to itchy, bleeding, scaly, and red lesions due to increased immune system activity. Existing topical treatments often result in side effects, emphasizing the necessity for advanced drug discovery in managing psori…
The discharge of untreated industrial wastewater into rivers in Malaysia presents significant environmental challenges, particularly concerning ammonium and phosphorus pollution in aquatic ecosystems, which entail ecological, economic, and health implications. Addressing these concerns, this research focuses on comprehensively characterizing diverse microorganisms within fermented fruit bio…